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- 200-01RA
- 2025年10月22日
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海研卉生物科技有限公司
- 英文名：
Recombinant Human IL-1RA
- 规格：
100µg
Recombinant Human IL-1RA
Product Details
Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein. It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors. IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts. Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease. Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.
Source: E.coli
AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE
Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.
Growth Factors & Cytokines
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
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| Morris, G E | Agonists of toll-like receptors 2 and 4 activate airway smooth muscle via mononuclear leukocytes. | American Journal of Respiratory and Critical Care Medicine; 171(8) pg814-22 | 15 Apr 2005 | 15657467 Show Usages |
| Uddin, J | Monocyte-astrocyte networks and the regulation of chemokine secretion in neurocysticercosis. | Journal of immunology (Baltimore, Md. : 1950); 175(5) pg3273-81 | 1 Sep 2005 | 16116219 Show Usages |
| Serantes, R | Interleukin-1beta enhances GABAA receptor cell-surface expression by a phosphatidylinositol 3-kinase/Akt pathway: relevance to sepsis-associated encephalopathy. | The Journal of Biological Chemistry; 281(21) pg14632-43 | 26 May 2006 | 16567807 Show Usages |
| O'Kane, C M | Monocyte-dependent fibroblast CXCL8 secretion occurs in tuberculosis and limits survival of mycobacteria within macrophages. | Journal of immunology (Baltimore, Md. : 1950); 178(6) pg3767-76 | 15 Mar 2007 | 17339475 Show Usages |
| Helmy, A | Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery. | Journal of Neurotrauma; 26(4) pg549-61 | 0 Apr 2009 | 19196175 Show Usages |
| Green, J A | Mycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks. | Journal of immunology (Baltimore, Md. : 1950); 184(11) pg6492-503 | 1 Jun 2010 | 20483790 Show Usages |
| Ersvaer, E | Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells. | BMC Immunology; 11 pg38 | 9 Jul 2010 | 20618967 Show Usages |
| Gilbert, L A | DNA damage-mediated induction of a chemoresistant niche. | Cell; 143(3) pg355-66 | 29 Oct 2010 | 21029859 Show Usages |
| Green, J A | Mycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways. | Journal of Neuroinflammation; 8 pg46 | 11 May 2011 | 21569377 Show Usages |
| Descamps, D | Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing. | Proceedings of the National Academy of Sciences of the United States of America; 109(5) pg1619-24 | 31 Jan 2012 | 22307620 Show Usages |
| Iyer, A | MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response. | PLoS ONE; 7(9) pge44789 | 0 2012 | 23028621 Show Usages |
| Unger, B L | Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1. | PLoS Pathogens; 8(10) pge1002969 | 0 2012 | 23055935 Show Usages |
| Chai, B | Trigeminal-rostral ventromedial medulla circuitry is involved in orofacial hyperalgesia contralateral to tissue injury. | Molecular Pain; 8 pg78 | 23 Oct 2012 | 23092240 Show Usages |
| Eigenbrod, T | Early inhibition of IL-1β expression by IFN-γ is mediated by impaired binding of NF-κB to the IL-1β promoter but is independent of nitric oxide. | Journal of immunology (Baltimore, Md. : 1950); 190(12) pg6533-41 | 15 Jun 2013 | 23667107 Show Usages |
| Jacamo, R | Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-κB mediates chemoresistance. | Blood; 123(17) pg2691-702 | 24 Apr 2014 | 24599548 Show Usages |
| Prieto, G A | Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus. | Proceedings of the National Academy of Sciences of the United States of America; 112(36) pgE5078-87 | 8 Sep 2015 | 26305968 Show Usages |
| Spalinger, M R | NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22. | The Journal of Clinical Investigation; 126(5) pg1783-800 | 2 May 2016 | 27043286 Show Usages |
| Young, H L | An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition. | The Journal of Experimental Medicine; 214(6) pg1691-1710 | 5 Jun 2017 | 28450382 Show Usages |
| Falahee, P C | α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in | Journal of immunology (Baltimore, Md. : 1950); 199(5) pg1772-1782 | 1 Sep 2017 | 28733486 Show Usages |
| Dang, T | Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt. | Scientific Reports; 8(1) pg7718 | 16 May 2018 | 29769604 Show Usages |
| Iriondo, O | TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis. | Nature Communications; 9(1) pg1994 | 18 May 2018 | 29777109 Show Usages |
| Cartmell, T | Interleukin-1 mediates a rapid inflammatory response after injection of adenoviral vectors into the brain. | The Journal of neuroscience : the official journal of the Society for Neuroscience; 19(4) pg1517-23 | 15 Feb 1999 | 9952427 Show Usages |
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