Anti-TXNIP antibody

Anti-TXNIP antibody

Cat. No.     JK262438  
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-TXNIP rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Synthetic peptide of human TXNIP
Reactivity                 Human, Mouse, Rat
Content                     1.9 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 TXNIP
Full name                 thioredoxin interacting protein
Synonyms    THIF; VDUP1; HHCPA78; EST01027
Swissprot    Q9H3M7

Target Background
May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells. Acts as a suppressor of tumor cell growth. Inhibits the proteasomal degradation of DDIT4, and thereby contributes to the inhibition of the mammalian target of rapamycin complex 1 (mTORC1).