Anti-HGF antibody

Anti-HGF antibody

Cat. No.    JK220741        
Package    25 μl/100 μl/200 μl
Storage    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Product overview
Description                   Anti-HGF rabbit polyclonal antibody
Applications        ELISA, IHC 
Immunogen               Fusion protein of human HGF
Reactivity                 Human, Mouse, Rat
Content                     0.8 mg/ml
Host species               Rabbit
Ig class                  Immunogen-specific rabbit IgG
Purification                 Antigen affinity purification

Target information
Symbol                 HGF
Full name                 hepatocyte growth factor (hepapoietin A; scatter factor)
Synonyms    SF; HGFB; HPTA; F-TCF; DFNB39
Swissprot    P14210

Target Background
Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule.