sigma试剂PD 98,059

PD 98,059

solid

Application

PD 98,059 has been used:
• in growth medium as a mitogen-activated protein (MAP) kinase inhibitor, in order to study the secondary messengers involved in the effect of D1-like receptors
• in calcium-free RPMI (Roswell park memorial institute)-1640 medium to study its effect on inflammation, proliferation and differentiation in human epidermal keratinocyte cell line in conjunction of cystic fibrosis transmembrane conductance regulator (CFTR) knockdown
• in culture medium for cell migration assay

包装

1, 5 mg in glass bottle

Biochem/physiol Actions

PD 98,059 is a flavonoid and specific inhibitor of mitogen-activated protein kinase kinase (MAPKK). In mice, PD 98,059 helps to block zymosan stimulated organ dysfunction syndrome and non-septic shock. It is known to inhibit in vitro hypertrophy. PD 98,059 also induces cartilage formation in mesenchymal stromal cells.

Features and Benefits

该化合物也作为Sigma′药理活性化合物库（LOPAC^®1280）的一部分提供，该化合物库是一个高品质即时筛选化合物的经生物学注释的集合。
 

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