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- 锐博生物
- siB***********
- 广州
- 2025年12月05日
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- 详细信息
- 询价记录
- 文献和实验
- 技术资料
- 保存条件：
-20℃~-80℃
- 规格：
5nmol
常规siRNA的结构多为19nt RNA + dTdT (3'悬垂) 的RNA双链分子，其中Sense链（正义链，RNA）序列与靶序列相同，Antisense链（反义链，RNA）序列与靶序列互补，在每条链的3'端还有一个dTdT悬垂。
常规化学合成siRNA 结构示例图
siRNA for Homo sapiens gene bcl-2-like protein 11（BCL2L11）
产品优势
1、采用siCatch™ siRNA design智能设计；
2、通过系统性优化，保证靶点特异性；
3、均经过严格的质谱检测，保证siRNA质量和纯度；
4、只需溶解，即可直接用于实验。
产品特性
■ 形式：双链，已退火
■ 剂型：冻干粉
■ 质控：LC-MS 质控管理
■ 使用：只需溶解，即可直接用于实验
化学合成siRNA 单链 LC-MS 质控结果
5nmol siRNA 的筛选次数参考表
| 孔板规格 | 6 | 12 | 24 | 96 |
| 工作浓度 | 50nM | 50nM | 50nM | 50nM |
| 筛选次数 | 50次 | 100次 | 200次 | 1000次 |
客户应用案例
案例1：基因特异性siRNA
ABCG5，ABCG8和ABCA1）的表达升高。
Wang JQ, et al. Nature, 2022.
案例2：lncRNA特异性siRNA
Xue S, et al. Molecular cancer, 2022.
案例3：circRNA特异性siRNA
Li X, et al. Molecular cancer, 2022.
订购信息
| 产品编号 | 产品名称 | 规格 | 目录价 |
| Varies | mRNA/lncRNA/circRNA siRNA, Standard, 5nmol | 5nmol | ¥589.00 |
| Varies | mRNA/lncRNA/circRNA siRNA, Standard, 5nmol | 5nmol*2 | ¥950.00 |
| Varies | mRNA/lncRNA/circRNA siRNA, Standard, 5nmol | 5nmol*4 | ¥1280.00 |
注：
1) 上述报价以19nt+3'overhangs（2nt）siRNA 作为标准，超过部分碱基按RNA oligo 合成单价的相应合成规格进行收费；
2) 如需化学修饰部分按化学修饰产品单价的相应合成规格进行收费；
3) Standard 纯化通常用于细胞实验，in vivo 纯化普遍适用于细胞或动物实验；
4) 如需咨询更大规格产品，可联系当地锐博销售人员。
代表性客户文章
[1] GE, Li-Ping, et al. ZNF689 deficiency promotes intratumor heterogeneity and immunotherapy resistance in triple-negative breast cancer. Cell Research, 2024, 1-18.
[2] XU, Zhi-Sheng, et al. LDLR is an entry receptor for Crimean-Congo hemo rrhagic fever v ir us. Cell Research, 2024, 1-11.
[3] LIN, Xiaolei, et al. Augmentation of scleral glycolysis promotes myopia through histone lactylation. Cell Metabolism, 2024.
[4] WANG, Ailian, et al. Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders. Nature Cell Biology, 2024, 1-16.
[5] GAO, Jinchao, et al. Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function. Nature Nanotechnology, 2023, 1-11.
[6] ZENG, Qin, et al. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell Metabolism, 2023, 35.5: 837-854. e8.
[7] LIU, Xuanyu, et al. Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics. Cell Discovery, 2023, 9.1: 6.
[8] Wang J Q, Li L L, Hu A, et al. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion[J]. Nature, 2022, 608(7922): 413-420.
[9] Qi Y, Ding L, Zhang S, et al. A plant immune protein enables broad antitumor response by rescuing microRNA deficiency[J]. Cell, 2022, 185(11): 1888-1904. e24.
[10] Ma S, Wang S, Ye Y, et al. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues[J]. Cell Stem Cell, 2022.
[11] Wu B, Li Y, Nie N, et al. SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration [J]. Cell discovery, 2022, 8(1): 1-16.
[12] Ren Y, Wang A, Wu D, et al. Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables eff icient virus r eplication[J]. Nature Microbiology, 2022: 1-13.
[13] Liu F, Tian T, Zhang Z, et al. Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma[J]. Nature Metabolism, 2022, 4(8): 1022-1040.
[14] Zhang D, Liu Y, Zhu Y, et al. A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and or gan fibrosis[J]. Nature Cell Biology, 2022, 24(5): 766-782.
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- 作者
- 内容
- 询问日期
文献和实验[2] XU, Zhi-Sheng, et al. LDLR is an entry receptor for Crimean-Congo hemo rrhagic fever v ir us. Cell Research, 2024, 1-11.
[3] LIN, Xiaolei, et al. Augmentation of scleral glycolysis promotes myopia through histone lactylation. Cell Metabolism, 2024.
[4] WANG, Ailian, et al. Innate immune sensing of lysosomal dysfunction drives multiple lysosomal storage disorders. Nature Cell Biology, 2024, 1-16.
[5] GAO, Jinchao, et al. Intracerebral fate of organic and inorganic nanoparticles is dependent on microglial extracellular vesicle function. Nature Nanotechnology, 2023, 1-11.
[6] ZENG, Qin, et al. Spleen fibroblastic reticular cell-derived acetylcholine promotes lipid metabolism to drive autoreactive B cell responses. Cell Metabolism, 2023, 35.5: 837-854. e8.
[7] LIU, Xuanyu, et al. Lineage-specific regulatory changes in hypertrophic cardiomyopathy unraveled by single-nucleus RNA-seq and spatial transcriptomics. Cell Discovery, 2023, 9.1: 6.
[8] Wang J Q, Li L L, Hu A, et al. Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion[J]. Nature, 2022, 608(7922): 413-420.
[9] Qi Y, Ding L, Zhang S, et al. A plant immune protein enables broad antitumor response by rescuing microRNA deficiency[J]. Cell, 2022, 185(11): 1888-1904. e24.
[10] Ma S, Wang S, Ye Y, et al. Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues[J]. Cell Stem Cell, 2022.
[11] Wu B, Li Y, Nie N, et al. SFRP4+ stromal cell subpopulation with IGF1 signaling in human endometrial regeneration [J]. Cell discovery, 2022, 8(1): 1-16.
[12] Ren Y, Wang A, Wu D, et al. Dual inhibition of innate immunity and apoptosis by human cytomegalovirus protein UL37x1 enables eff icient virus r eplication[J]. Nature Microbiology, 2022: 1-13.
[13] Liu F, Tian T, Zhang Z, et al. Long non-coding RNA SNHG6 couples cholesterol sensing with mTORC1 activation in hepatocellular carcinoma[J]. Nature Metabolism, 2022, 4(8): 1022-1040.
[14] Zhang D, Liu Y, Zhu Y, et al. A non-canonical cGAS–STING–PERK pathway facilitates the translational program critical for senescence and or gan fibrosis[J]. Nature Cell Biology, 2022, 24(5): 766-782.
