- ¥2980
- LMAI Bio
- LM-0246R-FITC
- 中国/美国/欧洲
- 2025年07月07日
- IF=1:50-200
- Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig,
- Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-0246R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-CRF/FITC
- 抗体名：
Anti-CRF/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig,
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-CRF/FITC |
| 中文名称 | FITC标记的促肾上腺皮质激素释放因子/促肾上皮质激素释放激素抗体 |
| 别 名 | Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-releasing factor; CRH1; CRH; Corticotropin-releasing hormone. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 研究领域 | 神经生物学 内分泌病 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Rabbit, Guinea Pig, |
| 产品应用 | IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 5/22kDa |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CRF |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Corticotropin-releasing hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus in response to stress. Marked reduction in this protein has been observed in association with Alzheimer disease and autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Apr 2010]. Function: This hormone from hypothalamus regulates the release of corticotropin from pituitary gland. Subunit: Interacts (via C-terminus) with CRFR1 (via N-terminalv extracellular domain). Subcellular Location: Secreted. Similarity: Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. Database links: Entrez Gene: 1392 Human Entrez Gene: 12918 Mouse Entrez Gene: 81648 Rat Omim: 122560 Human SwissProt: P06850 Human SwissProt: Q8CIT0 Mouse SwissProt: P01143 Rat Unigene: 75294 Human Unigene: 290689 Mouse Unigene: 10349 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CRF阳性神经元的胞体广泛分布于下丘脑的室旁核、背缝核和蓝斑核，这些区域也是去甲（NE）神经元与5－羟色胺（5－HT）神经元密集的区域。 CRF既具有神经递质的性质又具有神经激素的性质。CRF是联系神经系统与内分泌系统的桥梁，在情感障碍疾患如焦虑和抑郁的发病中发挥重要作用. |
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文献和实验促肾上腺皮质激素检测的临床意义： ACTH的分泌受下丘脑激素促皮质释放因子（CRF）和皮质醇的反馈影响。ACTH对于鉴别诊断肾上腺功能减退和分泌亢进很有价值。在原发性肾上腺功能不全中，典型表现是ACTH水平升高，而低水平的ACTH通常见于垂体功能障碍继发的肾上腺功能不全。ACTH检测还能帮助鉴别cushing综合症中皮质醇分泌过多的原因，当皮质醇分泌过多是由肾上腺皮质病变或增生引起时，ACTH水平特征性地降低，而如果是由垂体异位生成ACTH或ACTH分泌过多引起时，ACTH水平
颗粒，用免疫细胞化学方法可将前叶的细胞进一步分为：①促生长素细胞，分泌生长素（GH）；②催乳素细胞，分泌催乳素（PRL）。以上两种细胞多嗜酸性；③促甲状腺素细胞，分泌促甲状腺素（TSH）；④促性激素细胞，分泌促卵泡素（FSH）及促黄体素（LH）；⑤促肾上腺皮质激素细胞，分泌促肾上腺皮质激素（ACTH）及促脂解激素（LPH）。第3、4、5种细胞多嗜碱性。大约有一半的嫌色细胞有稀少的分泌颗粒，另一半不见分泌颗粒，无内分泌功能。中间部及结节部也有一些含分泌颗粒的细胞，其功能尚不太清楚。 一、下丘脑及垂体
）促肾上腺皮质激素释放激素 促肾上腺皮质激素释放激素（corticotropin releasing hormone,CRH）为四十一肽，其主要作用是促进腺垂体合成与释放促肾上腺皮质激素（ACTH）。腺垂体中存在大分子的促阿片-黑素细胞皮质素原(pro-opiomelanocortin,POMC)，简称阿黑皮素原。在CRHA作用下经酶分解了ACTH、溶脂激素(lipotropin,β-LPH)和少量的β-内啡肽。静脉注射CRH5-20min后，血中ACTH浓度增加5-20倍。 分泌CRH
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