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- 详细信息
- 文献和实验
- 技术资料
- 保存条件:
We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃.
- 保质期:
Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
- 英文名:
Recombinant Human Interleukin-15 protein (IL15) (Active)
- 库存:
200
- 供应商:
武汉华美生物工程有限公司
- 规格:
10μg
英文名称:
Recombinant Human Interleukin-15 protein (IL15) (Active)品名简称:
Recombinant Human IL15 protein (Active)货号:
CSB-AP001621HU规格:
10μg价格:
2124LC-MS/Western Blot:
/SDS-PAGE:
/纯度:
>97% as determined by SDS-PAGE.内毒素:
Less than 1.0 EU/μg as determined by LAL method.生物活性:
Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay using murine CTLL-2 cells is less than 0.5 ng/ml, corresponding to a specific activity of > 2.0 × 106 IU/mg.基因名:
IL15Uniprot No.:
P40933别名:
IL-15,种属:
Homo sapiens (Human)蛋白长度:
Full Length of Mature Protein来源:
E.Coli分子量:
12.9 kDa表达区域:
49-162aa氨基酸序列:
NWVNVISDLKKIEDLIQSMHIDATLYTESDVHPSCKVTAMKCFLLELQVISLESGDASIHDTVENLIILANNSLSSNGNVTESGCKECEELEEKNIKEFLQSFVHIVQMFINTS蛋白标签:
Tag-Free产品提供形式:
Lyophilized powder缓冲液:
Lyophilized from a 0.2 µm filtered PBS, pH 7.4储存条件:
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.保质期:
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.货期:
5-10 business days注意事项:
Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.功能1:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.功能2:
Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.文献:
/研究领域:
Immunology请点击“在线询价”找客服索取产品说明书及引用文献目录,产品实时更新参数、价格信息、更多文献信息可以查看cusabio官网
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文献和实验有氧运动真的能抗癌!Cancer Cell:一周 5 次、每次 30 分钟,就可助力免疫系统杀死癌细胞
癌化疗效果 近年来,IL15 信号通路在肿瘤中的作用日益清晰,科学家已经尝试通过直接注射 IL15 治疗癌症,但却会引发严重的系统性炎症损伤。 IL15 与 T 细胞或 NK 细胞等免疫细胞存在蛋白与受体蛋白的「锁钥相互作用」,即 IL-15 与 IL-15Rα 相互作用,激活受体细胞。基于此,诺华制药开发了一种「超级激动剂」——NIZ985。NIZ985 能够增强 IL-15/IL-15Rα 信号通路,同时降低潜在的炎症反应。相关研究尚未在胰腺癌患者中进行大规模检测。 吉西他滨和白蛋白
基础。 传统的NK细胞扩增技术是在NK细胞培养体系中添加IL2、IL15等细胞因子以促进NK细胞增殖,但由于扩增效率不高且纯度不够未能得到广泛应用。近年来,有人采用基因工程的方法在K562细胞上同时表达IL-15、CD137L 等分子, 并以此细胞来刺激NK细胞的增殖。IL-15和CD137L联合刺激是PBMC 中NK细胞特异性扩增的基础:作为膜蛋白,通过细胞间的接触刺激,用以诱导NK细胞扩增。IL15能够促进NK细胞的分化成熟,而IL21能够联合IL15分子促进NK细胞的分化成熟,所以本研究在稳定
15 秒止血!MIT 赵选贺团队受自然启发,研制出如此神奇的
Biomed Eng主要研究内容藤壶胶样的生物粘合剂及其止血性能该生物粘合剂由疏水的油性基质和生物黏合剂微粒组成,它们分别与藤壶胶中富含脂质的基质和黏附蛋白具有相似的功能。其形态为可注射的膏状物,借助温和的压力,疏水的油性基质能够排斥血液,从而使压实的生物黏合剂微粒相互作用,并与组织表面彼此交联,在 15 秒内形成牢固的黏附,而不需要额外的辅助。这种排斥交联机制使藤壶胶生物黏合剂具有快速和不依赖体内凝血系统的止血能力。图片来源:Nat Biomed Eng为了研究疏水的油性基质和生物黏合剂微粒对止血的作用
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