Acetyl-CoA Carboxylase Antibod

Selective Modification of Fatty Acid Synthesis Pathway by Expression of an Acetyl-CoA Carboxylase-Specific Ribozyme Gene

The study of cellular function of a particular gene can be advanced by either specifically eliminating or blocking the function of its gene product. Although antisense RNA has frequently been used for this purpose, the hammerhead ribozyme

羧化酶 carboxylase

单酰 CoA＋ ADP 磷酸。  

丙酮酸羧化酶 pyruvate carboxylase

　　 存在于线粒体中，是催化下列不可逆反应的酶。 EC6． 4． 1． 1．丙酮酸＋ CO2 ＋ ATP＋ H2 O→草酰乙酸＋ ADP＋ Pi，Δ Go ′＝ -0.5kcal．广泛存在于动物、霉菌和酵母中，但在植物体和大部分细菌中却不含此酶。在三羧酸循环中，它是供给草酰乙酸的主要补充反应。为一种变构酶，有乙酰 CoA时，其活性存在，同时含有生物素作为和 CO2 反应的酶的辅酶。分子量约 65万，有很多亚基。最适 pH为 4.8。