Product overview Description Anti-IKZF3 rabbit polyclonal antibody Applications ELISA, IHC Immunogen Fusion protein of human IKZF3 Reactivity Human, Mouse Content 1.6 mg/ml Host species Rabbit Ig class Immunogen-specific rabbit IgG Purification Antigen affinity purification
Target information Symbol IKZF3 Full name IKAROS family zinc finger 3 (Aiolos) Synonyms AIO; AIOLOS; ZNFN1A3 Swissprot Q9UKT9
Target Background This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. Several alternative transcripts encoding different isoforms have been described, as well as some non-protein coding variants.
Applications Immunohistochemistry Predicted cell location: Cytoplasm Positive control: Human thyroid cancer Recommended dilution: 50-200 Predicted cell location: Cytoplasm Positive control: Human liver cancer Recommended dilution: 50-200
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using ml221936(IKZF3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using ml221936(IKZF3 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)