- ¥2980
- LMAI Bio
- LM-5231R-FITC
- 中国/美国/欧洲
- 2025年07月15日
- Flow-Cyt=1:50-200 IF=1:50-200
- Human, Mouse,
- Human, Mouse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 靶点：
详见说明书
- 级别：
1
- 目录编号：
LM-5231R-FITC
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Anti-phospho-Bid (Ser61)/FITC
- 抗体名：
Anti-phospho-Bid (Ser61)/FITC
- 标记物：
FITC标记
- 宿主：
Human, Mouse,
- 适应物种：
Human, Mouse,
- 免疫原：
详见说明书
- 亚型：
IGg
- 形态：
粉末、液体、冻干粉
- 应用范围：
Flow-Cyt=1:50-200 IF=1:50-200
- 浓度：
1mg/ml
- 保存条件：
-20 °C
- 规格：
100ul
| 英文名称 | Anti-phospho-Bid (Ser61)/FITC |
| 中文名称 | FITC标记的磷酸化BH3结构域凋亡诱导蛋白抗体 |
| 别 名 | Bid (phospho S61); p-Bid (phospho S61); BH3 interacting domain death agonist; p22 BID; BID;) BH3-interacting domain death agonist; AltName: BH3-interacting domain death agonist p15; BH3-interacting domain death agonist p13; p13 BID; BH3-interacting domain death agonist p11; p11 BID. |
| 规格价格 | 100ul/2980元 购买 大包装/询价 |
| 说 明 书 | 100ul |
| 产品类型 | 磷酸化抗体 |
| 研究领域 | 肿瘤 细胞生物 免疫学 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, |
| 产品应用 | Flow-Cyt=1:50-200 IF=1:50-200 not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 21kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated Synthesised phosphopeptide derived from mouse Bid around the phosphorylation site of Ser61 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| 产品介绍 | background: Bid, a BH3 domain containing proapoptotic Bcl2 family member, is localized in the cytosolic fraction of cells as an inactive precursor. Its active form is generated upon proteolytic cleavage by caspase 8 in the Fas signaling pathway. Cleaved Bid translocates to mitochondria and releases its potent proapoptotic activity, which in turn induces cytochrome c release and mitochondrial damage. The cytochrome c releasing activity of Bid was antagonized by Bcl2. Mutation in the SH3 domain can diminish the cytochrome c releasing activity. In animal model studies, Bid deficient mice are found resistant to the lethal effects of death factor signals relayed through Fas. Function: The major proteolytic product p15 BID allows the release of cytochrome c. Isoform 1, isoform 2 and isoform 4 induce ICE-like proteases and apoptosis. Isoform 3 does not induce apoptosis. Counters the protective effect of Bcl-2. Subunit: Forms heterodimers either with the pro-apoptotic protein BAX or the anti-apoptotic protein Bcl-2. Subcellular Location: Cytoplasm (By similarity). Mitochondrion membrane. Note=When uncleaved, it is predominantly cytoplasmic. BH3-interacting domain death agonist p15: Mitochondrion membrane. Note=Translocates to mitochondria as an integral membrane protein. BH3-interacting domain death agonist p13: Mitochondrion membrane. Note=Associated with the mitochondrial membran. Isoform 1: Cytoplasm. Isoform 3: Cytoplasm. Isoform 2: Mitochondrion membrane. Note=A significant proportion of isoform 2 localizes to mitochondria, it may be cleaved constitutively. Tissue Specificity: Isoform 2 and isoform 3 are expressed in spleen, bone marrow, cerebral and cerebellar cortex. Isoform 2 is expressed in spleen, pancreas and placenta (at protein level). Isoform 3 is expressed in lung, pancreas and spleen (at protein level). Isoform 4 is expressed in lung and pancreas (at protein level). Post-translational modifications: TNF-alpha induces a caspase-mediated cleavage of p22 BID into a major p15 and minor p13 and p11 products. Phosphorylated upon DNA damage, probably by ATM or ATR. Database links: Entrez Gene: 637 Human Entrez Gene: 12122 Mouse Entrez Gene: 64625 Rat Omim: 601997 Human SwissProt: P55957 Human SwissProt: P70444 Mouse SwissProt: Q9JLT6 Rat Unigene: 591054 Human Unigene: 235081 Mouse Unigene: 31142 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验凋亡，是沟通死亡受体通路和线粒体通路的中介者。Bid存在于胞质中，可以被caspases-8和caspase-3等水解而活化。活化的Bid从胞质进入到线粒体，诱导细胞色素C的释放，启动凋亡的发生。Bid基因敲除的小鼠肝细胞对Fas和TNF诱导的凋亡产生耐受，但对线粒体凋亡诱导剂仍然敏感。说明凋亡的诱导可以通过细胞膜产生，也可以通过线粒体直接产生，两者既相互独立，又互有联系。Bad有磷酸化和去磷酸化两种形式。在缺乏生存信号(survival signal)时，Bad以去磷酸化的形式存在。Bad的BH3域
还是不全面的，目前比较清楚的通路 主要有： 1)细胞凋亡的膜受体通路：各种外界因素是细胞凋亡的启动剂，它们可以通过不同的信号传递系统传递凋亡信号，引起细胞凋亡，我们以Fas -FasL为例： Fas是一种跨膜蛋白，属于肿瘤坏死因子受体超家族成员，它与FasL结合可以启动凋亡信号的转导引起细胞凋亡。它的活化包括一系列步骤：首先配体诱导受体三聚体化，然后在细胞膜 上形成凋亡诱导复合物，这个复合物中包括带有死亡结构域的Fas相关蛋白FADD。Fas又称CD95，是由325
tissue，human testis tissue，human brain tissue IF：Hela，HepG2 另外有 HRP、FITC、Bintin 标记的多抗对应货号分别为： CSB-PA07179B0Rb、CSB-PA07179C0Rb、CSB-PA07179D0Rb 兔抗人淀粉样肽 beta A4 蛋白单克隆抗体 货号：CSB-MA0019501A0m 识别
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