- 询价
- 上海博湖
- BH-K22832
- 进口、国产
- 2025年07月16日
- WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 详见说明书
- 详见说明书
9 年钻石会员
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
- 详细信息
- 文献和实验
- 技术资料
- 抗体名：
P物质抗体图片
- 抗体英文名：
Anti-Substance P
- 靶点：
详见说明书
- 浓度：
1mg/1ml
- 应用范围：
WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
- 宿主：
详见说明书
- 供应商：
上海博湖
- 库存：
大量
- 级别：
详见说明书
- 目录编号：
详见说明书
- 抗原来源：
Rabbit
- 保质期：
详见说明书
- 适应物种：
详见说明书
- 标记物：
详见说明书
- 克隆性：
多克隆
- 保存条件：
Store at -20 °C
- 形态：
详见说明书
- 亚型：
IgG
- 免疫原：
KLH conjugated synthetic peptide derived from human SP C-terminus
- 规格：
0.2ml/200μg
英文名称 Anti-Substance P
中文名称 P物质抗体图片
别 名 Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; Neuropeptide K; NK2; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.
P物质抗体图片浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg 1ml/1mg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, G
产品类型 一抗
研究领域 神经生物学 新陈代谢
蛋白分子量 predicted molecular weight: 14kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SP C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
P物质抗体图片产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.
Function : Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Location : Secreted.
Similarity : Belongs to the tachykinin family.
Database links :
Entrez Gene: 6863 Human
Entrez Gene: 21333 Mouse
Entrez Gene: 24806 Rat
Omim: 162320 Human
SwissProt: P20366 Human
SwissProt: P41539 Mouse
SwissProt: P06767 Rat
Unigene: 2563 Human
UniProtKB/Swiss-Prot: P20366.1
P物质（Substance P）是脑组织及消化道中发现的一种神经递质肽。由130个氨基酸残基组成，胃肠道中肌肉收缩的有力促进剂，亦为强血管扩张剂。
SP是一种脑肠肽，亦是最早发现的一种神经肽，属于速激肽家族成员，它广泛分布于中枢及外周神经系统，作为一种神经递质或调质参与疼痛、免疫、心血管等多种生理功能的调节。SP与其它的递质或调质类似，能作用于多种类型的受体，速激肽家族有NK1、NK2、NK3三种受体，都能与SP结合，其中NK1与SP的结合能力最强而被称为SP受体。
P物质抗体图片抗体的鉴定：
1）抗体的效价鉴定：不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2）抗体的特异性鉴定：抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3）亲和力：是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属：
兔抗单克隆抗体，鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体：HRP标记抗体，Biotin标记抗体，Gold标记抗体，RBITC标记抗体，AP标记抗体,FITC标记抗体，Cy3标记抗体，Cy5标记抗体，Cy5.5标记抗体，Cy7标记抗体，PE标记抗体，PE-Cy3标记抗体，PE-Cy5标记抗体，PE-Cy5.5标记抗体，PE-Cy7标记抗体，APC标记抗体，AlexaFluor 350标记抗体，Alexa Fluor 488标记抗体，Alexa Fluor 555标记抗体，Alexa Fluor647标记抗体 抗体的交叉反应： 人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等...... 抗体的应用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。
P物质抗体图片实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
Anti-Secretin/FITC 荧光素标记分泌素抗体IgGMulti-class antibodies规格： 0.2ml
多肽产品 多肽产品Multi-class antibodies规格： Peptide products
线粒体核糖体蛋白L28抗体 Anti-MrpL28 1ml
SNX27 英文名称： SNX27蛋白抗体 0.2ml
FGF13 英文名称： 纤维母细胞生长因子13抗体 0.2ml
Rhesus antibody Rh Phospho-PDGF Receptor beta (Tyr1009) 化血小板源性生长因子受体-B抗体 规格 0.1ml
多肽产品 多肽产品Multi-class antibodies规格： Peptide products
FLG(filaggrin)peptide 丝聚蛋白/中间丝蛋白抗原Multi-class antibodies规格： 0.5mg
脱氧尿苷单克隆抗体 Anti-BrdU 0.1ml
Rhesus antibody Rh phospho-DOK1(Tyr362) 化D酪酸激酶衰减蛋白1抗体 规格 0.1ml
PVDF膜(30cm×3m 0.45um) 1卷 Pall-Gelman
ZNF420 英文名称： 指蛋白420抗体 0.2ml
DBPA 英文名称： 冷休克蛋白DBPA抗体 0.2ml
脱氧尿苷单克隆抗体 Anti-BrdU 0.1ml
ZNF749 英文名称： 指蛋白749抗体 0.2ml
DAGLA 英文名称： 神经干细胞树突调节蛋白DAGLα抗体 0.2ml
活化蛋白C抗体 Anti-APC 0.1ml
Anti-HBeAg/FITC 荧光素标记小鼠抗人乙肝e抗原抗体(1)IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-Ephrin B(Tyr324/329) 化Ephrin B抗体 规格 0.1ml
Des(Desmin) 结蛋白抗原Multi-class antibodies规格： 0.5mg
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
Function : E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41.
Subunit : Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interacts with CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. Interacts with UBE2M. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBW7) complex. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1.
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Widely expressed.
Similarity : Belongs to the RING-box family.
Contains 1 RING-type zinc finger.
Database links : UniProtKB/Swiss-Prot: P62877.1
Anti-A/H1N1-M2 Human /Biotin 生物素标记兔抗人A型人流感病毒H1N1-M2抗体IgGMulti-class antibodies规格： 0.2ml
PACAP-27/38 腺苷酸环化酶激活肽-27/38(抗原)Multi-class antibodies规格： 0.5mg
CD90抗体 Anti-Thy-1/CD90 0.1ml
SPDYA 英文名称： 细胞周期G2/M期快速诱导蛋白SPDYA抗体 0.2ml
ECE2 英文名称： 内皮素转化酶2抗体 0.1ml
Rhesus antibody Rh phospho-Kv2.1(Ty8) 化通道蛋白DRK1抗体 规格 0.1ml
PACAP-27/38 腺苷酸环化酶激活肽-27/38(抗原)Multi-class antibodies规格： 0.5mg
P物质抗体图片PCX/PODXL(Podocalyxin) 足细胞特异蛋白抗原Multi-class antibodies规格： 0.5mg
Anti-ATP4B ATP酶通道蛋白抗体Multi-class antibodies规格： 0.1ml
Rhesus antibody Rh phospho-ANAPC1(Ser377) 化细胞周期末期促进复合蛋白APC1抗体 规格 0.1ml
P53 浓缩液 0.1ml 进口分装
UBXD2 英文名称： UBX结构域域蛋白D2抗体 0.2ml
DRIP5 英文名称： 多巴胺受体相互作用蛋白5抗体 0.2ml
Anti-ATP4B ATP酶通道蛋白抗体Multi-class antibodies规格： 0.1ml
中文名称 P物质抗体图片
别 名 Hs.2563; Neurokinin 1; Neurokinin 2; Neurokinin A; Neurokinin alpha; Neuromedin L; Neuropeptide gamma; Neuropeptide K; NK2; NKA; NKNA; PPT; Protachykinin 1 precursor; Substance K; Substance P; TAC1; TAC2; Tachykinin 1; Tachykinin 2; Tachykinin precursor 1; Tachykinin1; TACI; TKN1_HUMAN.
P物质抗体图片浓 度 1mg/1ml
规 格 0.1ml/100μg 0.2ml/200μg 1ml/1mg
抗体来源 Rabbit
克隆类型 polyclonal
交叉反应 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep, Guinea Pig, G
产品类型 一抗
研究领域 神经生物学 新陈代谢
蛋白分子量 predicted molecular weight: 14kDa
性 状 Lyophilized or Liquid
免 疫 原 KLH conjugated synthetic peptide derived from human SP C-terminus
亚 型 IgG
纯化方法 affinity purified by Protein A
储 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
P物质抗体图片产品应用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500
（石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍 This gene encodes four products of the tachykinin peptide hormone family, substance P and neurokinin A, as well as the related peptides, neuropeptide K and neuropeptide gamma. These hormones are thought to function as neurotransmitters which interact with nerve receptors and smooth muscle cells. They are known to induce behavioral responses and function as vasodilators and secretagogues. Alternative splicing of exons 4 and/or 6 produces four known products of undetermined significance.
Function : Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles.
Subcellular Location : Secreted.
Similarity : Belongs to the tachykinin family.
Database links :
Entrez Gene: 6863 Human
Entrez Gene: 21333 Mouse
Entrez Gene: 24806 Rat
Omim: 162320 Human
SwissProt: P20366 Human
SwissProt: P41539 Mouse
SwissProt: P06767 Rat
Unigene: 2563 Human
UniProtKB/Swiss-Prot: P20366.1
P物质（Substance P）是脑组织及消化道中发现的一种神经递质肽。由130个氨基酸残基组成，胃肠道中肌肉收缩的有力促进剂，亦为强血管扩张剂。
SP是一种脑肠肽，亦是最早发现的一种神经肽，属于速激肽家族成员，它广泛分布于中枢及外周神经系统，作为一种神经递质或调质参与疼痛、免疫、心血管等多种生理功能的调节。SP与其它的递质或调质类似，能作用于多种类型的受体，速激肽家族有NK1、NK2、NK3三种受体，都能与SP结合，其中NK1与SP的结合能力最强而被称为SP受体。
P物质抗体图片抗体的鉴定：
1）抗体的效价鉴定：不管是用于诊断还是用于治疗,制备抗体的目的都是要求较高效价。不同的抗原制备的抗体,要求的效价不一。鉴定效价的方法很多,包括有试管凝集反应,琼脂扩散试验,酶联免疫吸附试验等。常用的抗原所制备的抗体一般都有约成的鉴定效价的方法,以资比较。如制备抗抗体的效价,一般就采用琼脂扩散试验来鉴定。
2）抗体的特异性鉴定：抗体的特异性是指与相应抗原或近似抗原物质的识别能力。抗体的特异性高,它的识别能力就强。衡量特异性通常以交叉反应率来表示。交叉反应率可用竞争抑制试验测定。以不同浓度抗原和近似抗原分别做竞争抑制曲线,计算各自的结合率,求出各自在IC50时的浓度,并按公式计算交叉反应率。
如果所用抗原浓度IC50浓度为pg/管,而一些近似抗原物质的IC50浓度几乎是无穷大时,表示这一抗血清与其他抗原物质的交叉反应率近似为0,即该血清的特异性较好。
3）亲和力：是指抗体和抗原结合的牢固程度。亲和力的高低是由抗原分子的大小,抗体分子的结合位点与抗原决定簇之间立体构型的合适度决定的。有助于维持抗原抗体复合物稳定的分子间力有氢键,疏水键,侧链相反电荷基因的库仑力,范德华力和空间斥力。亲和力常以亲和常数K表示,K的单位是L/mol。抗体亲和力的测定对抗体的筛选,确定抗体的用途,验证抗体的均一性等均有重要意义。
种属：
兔抗单克隆抗体，鼠抗单克隆抗体。兔抗多克隆抗体。抗体的浓度为1mg/ml。 抗体及相关标记抗体：HRP标记抗体，Biotin标记抗体，Gold标记抗体，RBITC标记抗体，AP标记抗体,FITC标记抗体，Cy3标记抗体，Cy5标记抗体，Cy5.5标记抗体，Cy7标记抗体，PE标记抗体，PE-Cy3标记抗体，PE-Cy5标记抗体，PE-Cy5.5标记抗体，PE-Cy7标记抗体，APC标记抗体，AlexaFluor 350标记抗体，Alexa Fluor 488标记抗体，Alexa Fluor 555标记抗体，Alexa Fluor647标记抗体 抗体的交叉反应： 人，小鼠，大鼠，鸡 ，狗，猪，羊，牛，兔等...... 抗体的应用：可以用于做石蜡切片免疫组化，冰冻切片免疫组化，Elisa，WB，免疫荧光等实验。
P物质抗体图片实验原理 :
（1）特异性结合抗原：抗体本身不能直接溶解或杀伤带有特异抗原的靶细胞，通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而，抗体可通过与病毒或毒素的特异性结合，直接发挥中和病毒的作用。
（2）活补体：IgM、IgG1、IgG2和IgG3可通过经典途径激活补体，凝聚的IgA、IgG4和IgE可通过替代途径激活补体。
（3）结合细胞：不同类别的免疫球蛋白，可结合不同种的细胞，参与免疫应答。
（4）可通过胎盘及粘膜：免疫球蛋白G（IgG）能通过胎盘进入胎儿血流中，使胎儿形成自然被动
免疫。免疫球蛋白A（IgA）可通过消化道及呼吸道粘膜，是粘膜局部抗感染免疫的主要因素。
（5）具有抗原性：抗体分子是一种蛋白质，也具有刺机体产生免疫应答的性能。不同的免疫球蛋白分子，各具有不同的抗原性。
（6）抗体对理化因子的抵抗力与一般球蛋白相同：不耐热，60～70℃即被破坏。各种酶及能使蛋白质凝固变性的物质，均能破坏抗体的作用。抗体可被中性盐类沉淀。在上常可用硫酸铵或硫酸钠从免疫血清中沉淀出含有抗体的球蛋白，再经透析法将其纯化。
Anti-Secretin/FITC 荧光素标记分泌素抗体IgGMulti-class antibodies规格： 0.2ml
多肽产品 多肽产品Multi-class antibodies规格： Peptide products
线粒体核糖体蛋白L28抗体 Anti-MrpL28 1ml
SNX27 英文名称： SNX27蛋白抗体 0.2ml
FGF13 英文名称： 纤维母细胞生长因子13抗体 0.2ml
Rhesus antibody Rh Phospho-PDGF Receptor beta (Tyr1009) 化血小板源性生长因子受体-B抗体 规格 0.1ml
多肽产品 多肽产品Multi-class antibodies规格： Peptide products
FLG(filaggrin)peptide 丝聚蛋白/中间丝蛋白抗原Multi-class antibodies规格： 0.5mg
脱氧尿苷单克隆抗体 Anti-BrdU 0.1ml
Rhesus antibody Rh phospho-DOK1(Tyr362) 化D酪酸激酶衰减蛋白1抗体 规格 0.1ml
PVDF膜(30cm×3m 0.45um) 1卷 Pall-Gelman
ZNF420 英文名称： 指蛋白420抗体 0.2ml
DBPA 英文名称： 冷休克蛋白DBPA抗体 0.2ml
脱氧尿苷单克隆抗体 Anti-BrdU 0.1ml
ZNF749 英文名称： 指蛋白749抗体 0.2ml
DAGLA 英文名称： 神经干细胞树突调节蛋白DAGLα抗体 0.2ml
活化蛋白C抗体 Anti-APC 0.1ml
Anti-HBeAg/FITC 荧光素标记小鼠抗人乙肝e抗原抗体(1)IgGMulti-class antibodies规格： 0.2ml
Rhesus antibody Rh phospho-Ephrin B(Tyr324/329) 化Ephrin B抗体 规格 0.1ml
Des(Desmin) 结蛋白抗原Multi-class antibodies规格： 0.5mg
E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M.
Function : E3 ubiquitin ligase component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins, including proteins involved in cell cycle progression, signal transduction, transcription and transcription-coupled nucleotide excision repair. The functional specificity of the E3 ubiquitin-protein ligase complexes depends on the variable substrate recognition components. As a component of the CSA complex promotes the ubiquitination of ERCC6 resulting in proteasomal degradation. Through the RING-type zinc finger, seems to recruit the E2 ubiquitination enzyme, like CDC34, to the complex and brings it into close proximity to the substrate. Probably also stimulates CDC34 autoubiquitination. May be required for histone H3 and histone H4 ubiquitination in response to ultraviolet and for subsequent DNA repair. Promotes the neddylation of CUL1, CUL2, CUL4 and CUL4 via its interaction with UBE2M. Involved in the ubiquitination of KEAP1, ENC1 and KLHL41.
Subunit : Part of a SCF complex consisting of CUL1, RBX1, SKP1 and SKP2. Part of a SCF-like complex consisting of CUL7, RBX1, SKP1 and FBXW8. Part of CBC(VHL) complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 or CUL5 and VHL. Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II. Part of multisubunit E3 ubiquitin ligase complexes with elongin BC complex (TCEB1 and TCEB2), CUL2 and MED8; elongin BC complex (TCEB1 and TCEB2), CUL5 and MUF1. Part of multisubunit complexes with elongin BC complex (TCEB1 and TCEB2), elongin A/TCEB3 or SOCS1 or WSB1 and CUL5. Interacts directly with CUL1 and probably also with CUL2, CUL3, CUL4A, CUL4B, CUL5 and CUL7. Probably interacts with CDC34. Interacts with COPS6. Component of the DCX DET1-COP1 ubiquitin ligase complex at least composed of RBX1, DET1, DDB1, CUL4A and COP1. Part of an E3 ligase complex composed of RBX1, DDB1, DDB2 and CUL4A or CUL4B. Interacts with UBE2M. Part of a SCF complex consisting of CUL1, FBXO3, RBX1 and SKP1; this complex interacts with PML via FBXO3. Interacts with human adenovirus early E1A protein; this interaction inhibits RBX1-CUL1-dependent elongation reaction of ubiquitin chains by the SCF(FBW7) complex. Component of the SCF(Cyclin F) complex consisting of CUL1, RBX1, SKP1 and CCNF. Identified in a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complex together with HINT1 and CDC34. Component of multiple BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes formed of CUL3, RBX1 and a variable BTB domain-containing protein. Part of the BCR(ENC1) complex containing ENC1. Part of the BCR(GAN) complex containing GAN. Part of the BCR(KLHL41) complex containing KLHL41. Part of the BCR(KEAP1) complex containing KEAP1.
Subcellular Location : Cytoplasm. Nucleus.
Tissue Specificity : Widely expressed.
Similarity : Belongs to the RING-box family.
Contains 1 RING-type zinc finger.
Database links : UniProtKB/Swiss-Prot: P62877.1
Anti-A/H1N1-M2 Human /Biotin 生物素标记兔抗人A型人流感病毒H1N1-M2抗体IgGMulti-class antibodies规格： 0.2ml
PACAP-27/38 腺苷酸环化酶激活肽-27/38(抗原)Multi-class antibodies规格： 0.5mg
CD90抗体 Anti-Thy-1/CD90 0.1ml
SPDYA 英文名称： 细胞周期G2/M期快速诱导蛋白SPDYA抗体 0.2ml
ECE2 英文名称： 内皮素转化酶2抗体 0.1ml
Rhesus antibody Rh phospho-Kv2.1(Ty8) 化通道蛋白DRK1抗体 规格 0.1ml
PACAP-27/38 腺苷酸环化酶激活肽-27/38(抗原)Multi-class antibodies规格： 0.5mg
P物质抗体图片PCX/PODXL(Podocalyxin) 足细胞特异蛋白抗原Multi-class antibodies规格： 0.5mg
Anti-ATP4B ATP酶通道蛋白抗体Multi-class antibodies规格： 0.1ml
Rhesus antibody Rh phospho-ANAPC1(Ser377) 化细胞周期末期促进复合蛋白APC1抗体 规格 0.1ml
P53 浓缩液 0.1ml 进口分装
UBXD2 英文名称： UBX结构域域蛋白D2抗体 0.2ml
DRIP5 英文名称： 多巴胺受体相互作用蛋白5抗体 0.2ml
Anti-ATP4B ATP酶通道蛋白抗体Multi-class antibodies规格： 0.1ml
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验相关实验
血浆P物质 【参考范围】放免法（血浆）：空腹70～300pmol/L. 【影响因素】P物质测定尚无公认的手段或药盒，医学教|育网搜集整理建议各实验室建立自己的参考范围。 【临床意义】1.血浆P物质浓度增高可见于胃肠内分泌肿瘤患者。 2.巨结肠病患者远端肠管P物质神经细胞及P物质含量明显减少。 3.帕金森病患者纹状体及黑质中P物质减少。
血浆P物质参考范围是医学检验技士会涉及到的知识点，医学教育|网搜集整理，请参考。 血浆P物质参考范围： 【参考范围】放免法（血浆）：空腹70～300pmol/L. 【影响因素】P物质测定尚无公认的手段或药盒，建议各实验室建立自己的参考范围。 【临床意义】1.血浆P物质浓度增高可见于胃肠内分泌肿瘤患者医`学教育网搜集整理。 2.巨结肠病患者远端肠管P物质神经细胞及P物质含量明显减少。 3.帕金森病患者纹状体及黑质中P物质减少。
1931 年由尤勒（ U.S.von Euler ）和加德姆（ J.H.Gaddum ）发现的肽类，存在于脑及肠管组织中，有降血压和肠管收缩作用。 1971 年从丘脑下部分离出 P 物质的一种，确定了如下结构： Arg-Pro-Lys- Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH 2 。这种物质有使神经元兴奋的强力作用，一般认为与化学递质有密切关系。由于初次单独分离出来的状态是粉状物，故称 P 物质。
技术资料暂无技术资料 索取技术资料
P物质抗体图片
询价
