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- 详细信息
- 文献和实验
- 技术资料
- 库存:
198
- 英文名:
Recombinant Rabbit T-lymphocyte Activation Antigen CD86
- 保质期:
长期
- 供应商:
北京百奥莱博科技有限公司
- 保存条件:
冻干蛋白置于-20℃以下可长期保存,室温
- 规格:
10μg|50μg|500μg|1mg
特别提示:包括重组兔B7-2(CD86)在内,本公司的所有产品仅可用于科研实验,严禁用于临床医疗及其他非科研用途!
产品名称:重组兔B7-2(CD86)
英文名称:Recombinant Rabbit T-lymphocyte Activation Antigen CD86
产品货号:重组兔B7-2(CD86)
产品规格:10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成,目的基因编码的Ala23-Arg246在C端含有His标签。
B7-2/CD86质量控制:>95%(还原性SDS-PAGE)
B7-2/CD86制剂:冻干品
B7-2/CD86保存:
冻干蛋白置于-20℃以下可长期保存,室温条件下可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天,可分装后置于-20℃保存三个月。
B7-2/CD86复溶:
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后,请根据用量分装冻存,避免反复冻融。
关于B7-2/CD86:
T-lymphocyte activation antigen CD86 (B7-2) is a glycosylated protein in the B7 family. B7 family members are transmembrane cell surface molecules that play important roles in immune activation and the maintenance of immune tolerance. It is highly expressed on activated antigen presenting cells. CD86 involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. It may play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. It is expressed by activated B-lymphocytes and monocytes and promoted by MARCH8 and results in endocytosis and lysosomal degradation.
除了重组兔B7-2(CD86),,我公司还供应以下相关产品:
名称:重组人FGF7(成纤维生长因子7)(KGF)
货号:JN0257
规格:10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备,目的基因编码的Cys32-Thr194表达纯化而来。
FGF-7/KGF质量控制:>95%(还原性SDS-PAGE)。
FGF-7/KGF制剂:冻干品
FGF-7/KGF保存:
冻干蛋白可在-20℃长期保存,室温也可稳定保存3周。
复溶蛋白溶液可在4~7℃保存2~7天。
复溶后建议分装冻存在-20℃,可保存3个月,应避免反复冻融。
FGF-7/KGF复溶:
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存,避免反复冻融。
关于FGF-7/KGF:
Fibroblast growth factor 7 (FGF7) is a secreted protein which is mainly located in epithelial cells and belongs to the heparin-binding growth factors family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. FGF7 is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. It is possible major paracrine effector of normal epithelial cell proliferation.
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文献和实验, while the second is provided by the B-cell activation antigens B7-1, or CD80 and B7-2, or CD86 by interaction with the T-cell surface molecules CD28 and CTLA4 Positive staining (normal): interdigitating dendritic cells in T zones of secondary lymphoid organs
瘤上清(ATCC号TIB120)、B7-2/CD86的杂交瘤上清(Pharmingen)、DEC-205的抗体(ATCC号HB290) 10. 解剖用品 11. 无菌纱布垫 12. 100mm培养皿(如Falcon) 13. 3ml注射器25G,5/8in(1.58cm)针头 14. 9in(23cm)巴氏吸管(填充棉花并高压灭菌) 15. Nytex滤器(3-40/26;Tetko)
,鼠单抗已从单纯的生物实验室科研及临床诊断发展到治疗性抗体药物。目前的抗体药物大多来源于小鼠或噬菌体展示库。2019 年 3 月,首个骆驼源纳米抗体 Cablivi 获得 FDA 批准上市。2019 年 10 月,迎来首个兔单抗药物 Beovu,是抗体药物发展历程中的一个里程碑。临床使用的大多数治疗用抗体均需进行体外亲和力成熟,以提高抗体的亲和力。这一过程耗时长(8-12 个月),最终亲和力在 10-9mol/L。而兔单抗不需经体外亲和力成熟,就能达到 10-11 至 10-13mol/L。另外,兔
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