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        CD86分子

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        3856
         CD86 分子
         
        CD86
        常用单克隆抗体或代号: FUN- 1,BU63,GR65;(B7- 2)
        主要表达细胞: Ba,M [B]
        分子质量(kDa)和结构: gp80(IgSF)
        功    能: CD28、CTLA- 4配体,提供T细胞共刺激信号
         
        CD86
        Summary: Costimulates IL-2 production and T cell proliferation
        Aka B7-2
        Ligand for CD28 (CD80 also binds CD28), CD152 (CTLA4)
        Induction of an immune response requires T cells to receive 2 sets of signals from antigen presenting cells. The first is delivered through the T-cell receptor complex, while the second is provided by the B-cell activation antigens B7-1, or CD80 and B7-2, or CD86 by interaction with the T-cell surface molecules CD28 and CTLA4
        Positive staining (normal): interdigitating dendritic cells in T zones of secondary lymphoid organs, Langerhans cells, peripheral blood dendritic cells, memory B cells, germinal center B cells, monocytes (higher levels after g-IFN), endothelial cells, activated T cells
        Reference: GeneCards

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