重组人小鼠大鼠Ⅲ型纤连蛋白结构域包含蛋白5(鸢尾素) Iri

特别提示：包括重组人小鼠大鼠Ⅲ型纤连蛋白结构域包含蛋白5(鸢尾素) Irisin(FNDC5)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人小鼠大鼠Ⅲ型纤连蛋白结构域包含蛋白5(鸢尾素) Irisin(FNDC5)
英文名称：Recombinant Human/Mouse/Rat Fibronectin type III domain-containing protein 5

产品货号：重组人小鼠大鼠Ⅲ型纤连蛋白结构域包含蛋白5(鸢尾素) Irisin(FNDC5)
产品规格：10μg|50μg|500μg|1mg

本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Asp32-Glu143在C端带有Fc标签。

Irisin/FNDC5质量控制：＞95%(还原性SDS-PAGE)

Irisin/FNDC5制剂：冻干品

Irisin/FNDC5保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Irisin/FNDC5复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Irisin/FNDC5：
Fibronectin type III domain-containing protein 5, the precursor of irisin, is a protein that is encoded by the FNDC5 gene.Human Irisin is synthesized as a 212 amino acid (aa) precursor encoding a type 1 transmembrane protein with a 121 aa extracellular domain (ECD), a 21 aa transmembrane domain, and a 39 aa cytoplasmic domain. The ECD of Irisin contains a fibronectin type III domain and multiple glycosylation sites. The ECD is proteolytically cleaved to release the 112 aa soluble Irisin hormone into circulation.Mature human, mouse share 100% sequence identity.Irisin induces expression of peroxisome proliferatoractivated receptor γ coactivator 1α (PGC1α) and uncoupling protein1(UCP1), mitochondrialassociated metabolic proteins. Irisin induces the transition of white adipose tissue into more metabolically active beige adipose tissue.Irisin also regulates neuronal cell differentiation and neurite outgrowth in the brain and is involved in the differentiation of osteoblasts.

除了重组人小鼠大鼠Ⅲ型纤连蛋白结构域包含蛋白5(鸢尾素) Irisin(FNDC5),，我公司还供应以下相关产品：



名称：重组小鼠白介素IL-1β(白细胞介素1β)
货号：JN0342
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备，目的基因编码的Val118-Ser269表达纯化而来。

IL-1 beta/IL-1F2质量控制：＞95%(还原性SDS-PAGE)。

IL-1 beta/IL-1F2制剂：冻干品

IL-1 beta/IL-1F2保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

IL-1 beta/IL-1F2复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于IL-1 beta/IL-1F2：
Interleukin-1 (IL-1) designates two proteins, IL-1α and IL-1β, which are the products of distinct genes, but recognize the same cell surface receptors. IL-1α and IL-1β are structurally related polypeptides that show approximately 25% homology at the amino acid level. Both proteins are produced by a wide variety of cells in response to stimuli such as those produced by inflammatory agents, infections, or microbial endotoxins. The proteins are synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17.5 kDa. The specific protease responsible for the processing of IL-1β, designated interleukin 1β-converting enzyme (ICE), has been described. Mature human and mouse IL-1β share approximately 75% amino acid sequence identity and human IL-1β has been found to be active on murine cell lines.