重组人热激蛋白β11(HSPB11)北京厂家

特别提示：包括重组人热激蛋白β11(HSPB11)在内，本公司的所有产品仅可用于科研实验，严禁用于临床医疗及其他非科研用途！

产品名称：重组人热激蛋白β11(HSPB11)
英文名称：Recombinant Human Heat Shock Protein beta-11
产品货号：JN2021
产品规格：10μg|50μg|500μg|1mg

本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Ser144在N端含有His标签。

HSPB11质量控制：＞95%(还原性SDS-PAGE)

HSPB11制剂：液体

HSPB11保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于HSPB11：
Heat Shock Protein β-11 (HSPB11) is a stress-responsive protein that is required to deal with proteotoxic stresses. HSPB11 is composed of an IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 and is detected in placenta. HSPB11 has beeb shown to form oligomeric complexes and prevent the aggregation of in vitro denaturated aldolase and glyceraldehyde-3-phosphate dehydrogenase in accordance with the chaperone model of HSPB1 and HSPB5. HSPB11 overexpression protected against etoposide-induced cell death that correlated with a decreased release of mitochondrial Cytochrome C into the cytosol. Inhibition of HSP90 function completely abrogated the protective effect of HSPB11. This data suggests that at least in the case of HSPB11, interaction with other chaperone machines besides HSPA1A may contribute to functional specificity and cellular functioning.

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