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- Abbiotec
- 美国
- 350046
- 2026年03月25日
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- 文献和实验
- 技术资料
- 保存条件：
Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C.
- 保质期：
参照说明书可保存1-2年
- 英文名：
Amylin Peptide (Feline)
- 库存：
一定量库存
- 供应商：
华拓生物
- 规格：
1 mg
| 产品名称： | Amylin Peptide (Feline) |
| 产品链接： | http://www.abbiotec.com/peptides/amylin%25252C-feline |
| 货号： | 350046 |
| 规格： | 1 mg |
| 产品描述： | Amylin, also called Islet or insulinoma amyloid polypeptide (IAPP), is a 37-amino acid monomeric polypeptide isolated from pancreatic amyloid, which is commonly found in the islet of patients with diabetes mellitus type II and in insulinomas. Amylin is derived from a larger propeptide precursor of 89 amino acids in humans. Immunostaining of amylin is found in islet amyloid and in cells of the islets of Langherans, where it colocolizes with insulin in islet B cells. |
| 序列： | Feline: H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Ile-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Ala-Ile-Leu-Ser-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (Cys2-Cys7) or H-KCNTATCATQRLANFLIRSSNNLGAILSPTNVGSNTY-NH2 (Cys2-Cys7) |
| 分子式： | C165H270N52O54S2 |
| 分子量： | 3910.45 g/mol |
| 纯度： | Purity > 95% by HPLC |
| 别名： | Islet amyloid polypeptide; Amylin; Diabetes-associated peptide; DAP; Insulinoma amyloid peptide; IAPP |
| 形态： | Each vial contains 1 mg of lyophilized solid packaged under an inert gas and supplied as a trifluoroacetate salt. |
| 溶解方法： | Distilled water for a solution up to 2 mg/ml, otherwise we recommend using acetonitrile. |
| 保存方法： | Store at -20°C. The product is hygroscopic and must be protected from light. Product is guaranteed one year from the date of shipment. Following reconstitution, aliquot and store at -20°C. |
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文献和实验Activating the NLRP3 Inflammasome Using the Amyloidogenic Peptide IAPP
an inflammasome complex that ultimately cleaves pro-IL-1β and pro-IL-18 into their mature, secreted forms. Here we describe a protocol by which one type of amyloidogenic peptide, islet amyloid polypeptide (IAPP, otherwise known as amylin) can be prepared and used
，经脂肪酸酰化技术优化，实现利拉鲁肽每日一次、司美格鲁肽每周一次的递进，正式开启肠促胰素治疗时代，打破了单纯减重的局限，在减脂的同时兼顾血糖调控、改善肝脏脂质代谢，实现了减重与代谢脏器获益的双重提升。与此同时，以替尔泊肽（GIP/GLP-1双靶点）为代表，并延伸至三靶点甚至五靶点激动剂、同时口服制剂与非肽类小分子的突破，正在打破注射给药的传统壁垒。 除减重的基础药效之外，保肌减脂、低副作用、改善肝脏代谢、长期安全性，成为新一代代谢减重药物的核心评价标准：由此针对胰淀素（amylin）、降钙素受体
Characterization of CGRP Receptor Binding
ligands. Also, some cell lines fail to express CGRP receptors after extensive passage. CGRP binding assays provide a rapid and easy approach for distinguishing between receptors for CGRP and related peptides such as adrenomedullin and amylin.
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