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- 详细信息
- 技术资料
- 英文名：
Recombinant Human IL-17F
- 供应商：
上海研卉生物科技
- 规格：
25µg
IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate the proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. The mature human IL-17F is a homodimeric protein with a total weight of 30.1 kDa, consisting of two 133 amino acid residue chains. E.coli-derived Recombinant Human IL-17F is a biologically active, non-glycosylated, disulfide-linked homodimeric protein containing 268 amino acids (30.1 kDa), including N-terminal methionine residues.
Source: E.coli
Synonyms: Interleukin-17F
AA Sequence (monomer): MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ
Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity: Measured by its ability to induce IL-6 production by NHDF cells.
| First Author | Title | Citation | Date | Pubmed |
|---|---|---|---|---|
| Kramer, J M | Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. | Journal of immunology (Baltimore, Md. : 1950); 179(10) pg6379-83 | 15 Nov 2007 | 17982023 Show Usages |
| Brucklacher-Waldert, V | Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. | Journal of immunology (Baltimore, Md. : 1950); 183(9) pg5494-501 | 1 Nov 2009 | 19843935 Show Usages |
| Ho, A W | IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. | Journal of immunology (Baltimore, Md. : 1950); 185(2) pg1063-70 | 15 Jul 2010 | 20554964 Show Usages |
| Edwards, L A | Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. | PLoS ONE; 5(11) pge15398 | 9 Nov 2010 | 21085698 Show Usages |
| Boggio, E | IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes. | Blood; 123(8) pg1178-86 | 20 Feb 2014 | 24363402 Show Usages |
| De Simone, V | Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. | Oncogene; 34(27) pg3493-503 | 0 Jul 2015 | 25174402 Show Usages |
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