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Recombinant Human IL-17F

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  • ¥2570
  • peprotech
  • 200-25
  • 美国
  • 2025年10月11日
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    • 详细信息
    • 文献和实验
    • 技术资料
    • 英文名

      Recombinant Human IL-17F

    • 供应商

      上海研卉生物科技

    • 规格

      25µg

    Recombinant Human IL-17F
    Catalog Number: 200-25
    Description:

    IL-17F, a member of the IL-17 family of structurally related cytokines, has been shown to stimulate the proliferation and activation of T cells and PBMCs. IL-17F also regulates cartilage matrix turnover and inhibits angiogenesis. The mature human IL-17F is a homodimeric protein with a total weight of 30.1 kDa, consisting of two 133 amino acid residue chains. E.coli-derived Recombinant Human IL-17F is a biologically active, non-glycosylated, disulfide-linked homodimeric protein containing 268 amino acids (30.1 kDa), including N-terminal methionine residues.

    Source: E.coli

    Synonyms: Interleukin-17F

    AA Sequence (monomer): MRKIPKVGHT FFQKPESCPP VPGGSMKLDI GIINENQRVS MSRNIESRST SPWNYTVTWD PNRYPSEVVQ AQCRNLGCIN AQGKEDISMN SVPIQQETLV VRRKHQGCSV SFQLEKVLVT VGCTCVTPVI HHVQ

    Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

    Biological Activity: Measured by its ability to induce IL-6 production by NHDF cells.

    Size
    5µg
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    1mg
    First Author Title Citation Date Pubmed
    Kramer, J M Cutting edge: identification of a pre-ligand assembly domain (PLAD) and ligand binding site in the IL-17 receptor. Journal of immunology (Baltimore, Md. : 1950); 179(10) pg6379-83 15 Nov 2007 17982023
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    Brucklacher-Waldert, V Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. Journal of immunology (Baltimore, Md. : 1950); 183(9) pg5494-501 1 Nov 2009 19843935
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    Ho, A W IL-17RC is required for immune signaling via an extended SEF/IL-17R signaling domain in the cytoplasmic tail. Journal of immunology (Baltimore, Md. : 1950); 185(2) pg1063-70 15 Jul 2010 20554964
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    Edwards, L A Delineation of the innate and adaptive T-cell immune outcome in the human host in response to Campylobacter jejuni infection. PLoS ONE; 5(11) pge15398 9 Nov 2010 21085698
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    Boggio, E IL-17 protects T cells from apoptosis and contributes to development of ALPS-like phenotypes. Blood; 123(8) pg1178-86 20 Feb 2014 24363402
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    De Simone, V Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth. Oncogene; 34(27) pg3493-503 0 Jul 2015 25174402
    Show Usages

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