Murine IL-17A Pre-Coated ELISA

The originally described IL-17 protein, now known as IL-17A, is a homodimer of two 136 amino acid chains that are secreted by activated T-cells, which act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. The BioGems Murine IL-17A Pre-Coated ELISA (Enzyme-Linked Immunosorbent Assay) kit is a solid phase immunoassay specially designed to measure Murine IL-17A with a 96-well strip plate that is pre-coated with rat monoclonal antibody specific for IL-17A. It contains E.coli-expressed recombinant Murine IL-17A. The detection antibody is a biotinylated goat polyclonal antibody specific for IL-17A. The kit is analytically validated with ready to use reagents.