- ¥1380 - 2200
- LMAI Bio
- LM-9932R
- 进口/国产
- 2025年12月29日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-9932R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
C11ORF46
- 抗体名：
11号染色体开放阅读框46抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human C11ORF46:21-120/260
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | C11ORF46 |
| 中文名称 | 11号染色体开放阅读框46抗体 |
| 别 名 | Chromosome 11 open reading frame 46; DJ299F11.1; FLJ38968; Hypothetical protein LOC120534; Uncharacterized protein C11orf46; AL14E_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 细胞凋亡 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 29kDa |
| 细胞定位 | 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human C11ORF46:21-120/260 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: C11orf46, also known as FLJ38968 or dJ299F11.1, is a 260 amino acid protein that is encoded by a gene located on human chromosome 11. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and β thalassemia are caused by HBB gene mutations. Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11. Function: Through its interaction with ARL14 and MYO1E, may connect MHC class II-containing cytoplasmic vesicles to the actin network and hence controls the movement of these vesicles along the actin cytoskeleton in dendritic cells. Subunit: Interacts with ARL14 and MYO1E. Subcellular Location: Cytoplasm. Tissue Specificity: Expressed in the immune system. SWISS: Q8N8R7 Gene ID: 120534 Database links: Entrez Gene: 120534 Human Omim: 612295 Human SwissProt: Q8N8R7 Human SwissProt: Q8BIX3 Mouse SwissProt: Q5FVK8 Rat Unigene: 502208 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (Mouse brain); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C11ORF46) Polyclonal Antibody, Unconjugated (bs-9932R) at 1:500 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. |
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文献和实验长度为1450bp即483个密码子，最长的是位于XII号染色体上的一个功能未知的开放阅读框(4910个密码子)，还有极少数的开放阅读框长度超过1500个密码子。在酵母基因组中，也有编码短蛋白的基因，例如，编码由40个氨基酸组成的细胞质 膜蛋白 脂质的PMP1基因。此外，酵母基因组中还包含：约140个编码RNA的基因，排列在XII号染色体的长末端；40个编码SnRNA的基因，散布于16条染色体；属于43个家族的275个tRNA基因也广泛分布于基因组中。 表1 酵母染色体
，即整个基因组有72％的核苷酸顺序由开放阅读框组成。这说明酿酒酵母基因要比其它高等真核生物基因排列紧密。如在人类基因组中，大约平均每隔30kb或更多的碱基才能发现一个编码蛋白质的基因。酵母基因组的紧密性是因为基因间隔区较短与基因中内含子稀少。酵母基因组的开放阅读框平均长度为483个密码子，最长的是位于XII号染色体上的一个功能未知的开放阅读框(4910个密码子)。此外，酿酒酵母基因组中还包含有大约140个编码rRNA的基因，排列在XII号染色体的长末端；40个编码snRNA（small nuclear
（1）Ph染色体（费城1号染色体）：Nowell及Hungerford于1960年发现慢性粒细胞性白血病（CML）血中有一个小于G组的染色体，由于首先在美国费城（Philadelphia）发现，故命名为Ph染色体。最初认为是22号染色体的长臂缺失所致，后经显带证明是9号和22号染色体长臂易位的结果。易位使9号染色体长臂（9q34）上的原癌基因abl和22号染色体(22q11)上的bcr(break point cluster region)基因重新组合成融合基因。后者具有增高了的酪氨酸激酶活性，这是慢性
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