The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
克隆性:
多克隆
供应商:
安诺伦(北京)生物科技有限公司
应用范围:
FC, FA
规格:
50 ug
研究领域:Adaptive Immunity
来源:Armenian Hamster IgM, kappa
存储溶液:Phosphate-buffered aqueous solution, ph7.2.
参考文献:Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., & Shirai, T. (1996). CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus. European journal of immunology, 26(12), 3061-3065.Ferlin, W. G., Severinson, E., Ström, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., & Howard, M. C. (1996). CD40 signaling induces interleukin‐4‐independent IgE switching in vivo. European journal of immunology, 26(12), 2911-2915.Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., & Takemori, T. (1996). Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells. European journal of immunology, 26(7), 1451-1458.
简单描述:The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.
Clone: HM40-3
Format: SAFIRE Purified
Cell Type: B Cells, Dendritic Cells, NK and NKT Cells, Monocytes and Macrophages