- ¥1380 - 2200
- LMAI Bio
- LM-8541R
- 进口/国产
- 2025年12月31日
- ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg/Test IF=1:50-200 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Cow, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8541R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
CLEC 4E
- 抗体名：
C型凝集素4家族E抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Cow, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human CLECSF9:51-150/219 <Extracellular>
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg/Test IF=1:50-200 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | CLEC 4E |
| 中文名称 | C型凝集素4家族E抗体 |
| 别 名 | C type lectin domain family 4 member E; C type lectin superfamily member 9; C-type (calcium dependent carbohydrate recognition domain) lectin superfamily member 9; C-type lectin domain family 4 member E; C-type lectin superfamily member 9; CLC4E_HUMAN; CLEC 4E; CLEC4E Clec4e; CLECSF9; Macrophage inducible C type lectin; Macrophage-inducible C-type lectin; MINCLE. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 细胞凋亡 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Cow, Horse, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=5μg/Test IF=1:50-200 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 25kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CLECSF9:51-150/219 <Extracellular> |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. Function: C-type lectin that functions as cell-surface receptor for a wide variety of ligands such as damaged cells, fungi and mycobacteria. Plays a role in the recognition of pathogenic fungi, such as Candida albicans. The detection of mycobacteria is via trehalose 6,6'-dimycolate (TDM), a cell wall glycolipid. Specifically recognizes alpha-mannose residues on pathogenic fungi of the genus Malassezia. Recognizes also SAP130, a nuclear protein, that is released by dead or dying cells. Transduces signals through an ITAM-containing adapter protein, Fc receptor gamma chain /FCER1G. Induces secretion of inflammatory cytokines through a pathway that depends on SYK, CARD9 and NF-kappa-B. Subunit: Monomer. Homodimer. Subcellular Location: Membrane. Similarity: Contains 1 C-type lectin domain. SWISS: Q9ULY5 Gene ID: 26253 Database links: Entrez Gene: 26253 Human Omim: 609962 Human SwissProt: Q9ULY5 Human Unigene: 236516 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Blank control: Hela(blue), the cells were fixed with 2% paraformaldehyde (10 min) and then permeabilized with ice-cold 90% methanol for 30 min on ice. Isotype Control Antibody: Rabbit IgG(orange) ; Secondary Antibody: Goat anti-rabbit IgG-PE(white blue), Dilution: 1:200 in 1 X PBS containing 0.5% BSA ; Primary Antibody Dilution: 5μg in 100 μL1X PBS containing 0.5% BSA(green). |
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文献和实验E- 选择素 (CD62E) E-选择素又称内皮细胞白细胞黏附分子-I(ELAM-1)，胞膜外区由1个C型凝集素样结构域、1个EGF样结构域和6个CCP组成，表达于炎症部位的内皮细胞。E-选择素通过其C型凝集素结构域同白细胞糖脂和糖蛋白上的唾液酸化路易糖(sLe)，以及唾液酸化的Lewis和相关的岩藻糖基化的N-乙酰乳糖胺结合。 E -选择素另一种糖蛋白配体是表达于髓样细胞的ESL-1蛋白(E-selectinligan&l
杀伤细胞凝集素样受体（ KLR ） 属C型凝集素家族成员，为Ⅱ型膜蛋白，由CD94和C型凝集素家族不同成员组成。CD94／NKG2A和CD94／NKG2B，由CD94和NKG2A或NKG2B以二硫键连接，两条肽链的膜外区各有一个C型凝集素样(C-lectin)结构域。其中NKG2A和NKG2B分子胞质区有2个ITIM；CD94无此结构，但起着分子伴侣的作用，对CD94／NKG2A的表达及功能行使是不可少的。 CD94／NKG
的PECAM-1、NCAM-1和NCAM-L1等分子。 选择素(selectin)最初称为凝集素细胞黏附分子(1ectincelladhesionmolecule，LEC-CAM)，为I型膜分子，胞膜外区均由3种结构域构成：①氨基端约120个氨基酸残基为钙离子依赖的C型外源凝集素样结构域，是选择素分子与配体的结合部位；②表皮生长因子样结构域(EGF-likedomain)，约含35个氨基酸残基，此结构域对维持选择素分子的构象是必需的；③近膜部分是数个约60个氨基酸残基构成的CCP结构域，其作用
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