- ¥1380 - 2200
- LMAI Bio
- LM-8534R
- 进口/国产
- 2025年12月31日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-8534R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
TRPV5
- 抗体名：
辣椒素受体5抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human TRPV5:201-300/729
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | TRPV5 |
| 中文名称 | 辣椒素受体5抗体 |
| 别 名 | Calcium transport protein 2; Calcium transporter 2; CAT 2; CAT2; ECAC 1; ECaC; ECAC1; Epithelial calcium channel 1; Osm 9 like TRP channel 3; Osm-9-like TRP channel 3; OTRPC 3; OTRPC3; Transient receptor potential cation channel subfamily V member 5; TRPV 5; TrpV5; TRPV5_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 神经生物学 转录调节因子 通道蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 83kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human TRPV5:201-300/729 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Transient receptor potential (TRP) proteins are cation-sensitive channels that modulate a myriad of cellular functions, including temperature sensation and vasoregulation Transcribed from a gene adjacent to VR-1, the thermal-sensitive, capsaicin-insensitive TRPV3 is expressed at warm temperatures; expression increases in response to noxious temperatures. Human TRPV3 is expressed in skin, tongue, dorsal root ganglion, trigeminal ganglion, spinal cord and brain. In addition, TRPV3 is co-expressed in dosal root ganglion neurons with VR-1. TRPV3 associates with VR-1 and may modulate VR-1 activity. The 729 amino acid TRPV5 (ECAC1) protein comprises six transmembrane domains, multiple potential phosphorylation sites, an N-linked glycosylation site and three ankyrin repeat regions. It is abundantly expressed in kidney, jejunum and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. TRPV5 controls the rate-limiting step of vitamin D3-regulated Ca2+ reabsorption in kidney and intestine; the 5’-flanking region of TRPV5 contains four putative vitamin D3-responsive elements. Function: Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)-dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating. Subunit: Homotetramer and probably heterotetramer with TRPV6. Interacts with TRPV6. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmodulin. Interacts with BSPRY, which results in its inactivation (By similarity). Subcellular Location: Apical cell membrane. Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. Tissue Specificity: Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. Post-translational modifications: Glycosylated. Similarity: Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV5 sub-subfamily. Contains 5 ANK repeats. SWISS: Q9NQA5 Gene ID: 56302 Database links: Entrez Gene: 56302 Human Entrez Gene: 194352 Mouse Entrez Gene: 116469 Rat Omim: 606679 Human SwissProt: Q9NQA5 Human SwissProt: P69744 Mouse SwissProt: Q9JIP0 Rat Unigene: 283369 Human Unigene: 135734 Mouse Unigene: 137513 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Blank control(blue): 293T Cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-TRPV5/AF488 Conjugated antibody (bs-8534R-AF488), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF488(orange) ,used under the same conditions.  Blank control(blue): 293T Cells(fixed with 2% paraformaldehyde (10 min)). Primary Antibody: Rabbit Anti-TRPV5/AF488 Conjugated antibody (bs-8534R-AF488), Dilution: 1μg in 100 μL 1X PBS containing 0.5% BSA; Isotype Control Antibody: Rabbit IgG/AF488(orange) ,used under the same conditions. |
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文献和实验人乙酰胆碱脂酶受体抗体（AchR-Ab）酶联免疫分析（ELISA）
人 乙酰胆碱脂酶受体抗体（ AchR-Ab ） 酶联免疫分析（ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中乙酰胆碱脂酶受体抗体（AchR-Ab ）的 含量。 实验原理： 本试剂盒应用双抗原夹心法测定标本中人乙酰胆碱脂酶受体抗体（ AchR-Ab ） 水平。 用纯化的抗原包被微孔板，制成固相抗原，往包被单抗的微孔中依次加入抗乙酰胆碱脂酶受体抗体
抗体的轻、重链嵌合基因共转染受体细胞 目前将重组子导入宿主细胞主要采用的方法有磷酸钙沉淀法、DEAE-葡聚糖街道法介导法、聚季铵盐介导法、原生质体融合法、电转染法以及微注射法。其中以电转染效率较高。 【材料和试剂】 （1） 小鼠骨髓瘤细胞系Sp2/0细胞或P3X63.Ag8.653细胞，或CHO细胞。 （2） 已构建的轻、重链嵌合基因质粒DNA。 （3） 脂质体。 （4） 电转
与辣椒素反应的蛋白质的 DNA 片段，经过艰苦的搜索，他们最终确定了一个能够使细胞对辣椒素敏感的基因。辣椒素感应基因由此被科学家们发现！进一步的实验表明，鉴定出的感应基因编码了一种新的离子通道蛋白，这种新发现的辣椒素受体后来被命名为 TRPV1。当朱利叶斯研究这种蛋白质对热的反应能力时，他意识到他发现了一种热敏受体，这种受体在感觉疼痛的温度下会被激活。学者简介David J. Julius 美国生理学家。加利福尼亚大学旧金山分校教授，发现了产生痛觉的细胞信号机制。曾获邵逸夫生命科学及医学
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