- ¥1380 - 2200
- LMAI Bio
- LM-7879R
- 进口/国产
- 2025年12月02日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-7879R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
SUPT16H
- 抗体名：
染色体特异性转录延伸因子抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish,
- 免疫原：
KLH conjugated synthetic peptide derived from human SUPT16H/CDC68:601-700/1047
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | SUPT16H |
| 中文名称 | 染色体特异性转录延伸因子抗体 |
| 别 名 | CDC68; Chromatin specific transcription elongation factor 140 kDa subunit; Chromatin-specific transcription elongation factor 140 kDa subunit; Facilitates chromatin transcription complex subunit SPT16; FACT 140 kDa subunit; FACT; FACT complex subunit SPT16; FACTP140; FLJ10857; FLJ14010; hSPT16; SP16H_HUMAN; Suppressor of Ty 16 homolog; Supt16h. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 细胞周期蛋白 转录调节因子 细胞分化 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Zebrafish, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 120kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human SUPT16H/CDC68:601-700/1047 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Function: Component of the FACT complex, a general chromatinfactor that acts to reorganize nucleosomes. The FACT complex isinvolved in multiple processes that require DNA as a template suchas mRNA elongation, DNA replication and DNA repair. Duringtranscription elongation the FACT complex acts as a histonechaperone that both destabilizes and restores nucleosomalstructure. It facilitates the passage of RNA polymerase II andtranscription by promoting the dissociation of one histone H2A-H2Bdimer from the nucleosome, then subsequently promotes thereestablishment of the nucleosome following the passage of RNApolymerase II. The FACT complex is probably also involved inphosphorylation of 'Ser-392' of p53/TP53 via its association withCK2 (casein kinase II). Also involved in vitamin D-coupledtranscription regulation via its association with the WINACcomplex, a chromatin-remodeling complex recruited by vitamin Dreceptor (VDR), which is required for the ligand-bound VDR-mediatedtransrepression of the CYP27B1 gene (By similarity). Subunit: Component of the FACT complex, a stable heterodimer ofSSRP1 and SUPT16H. Also component of a CK2-SPT16-SSRP1 complexwhich forms following UV irradiation, composed of SSRP1, SUPT16H,CSNK2A1, CSNK2A2 and CSNK2B. Component of the WINAC complex, atleast composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2,SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A andTOP2B. Interacts with NEK9. Binds to histone H2A-H2B. Interactswith GTF2E2. Subcellular Location: Nucleus. Chromosome. Note=Colocalizes withRNA polymerase II on chromatin. Recruited to actively transcribedloci. Tissue Specificity: Ubiquitous. Post-translational modifications: ADP-ribosylated. ADP-ribosylation by PARP1 is induced bygenotoxic stress and correlates with dissociation of FACT fromchromatin. Similarity: Belongs to the peptidase M24 family. SPT16 subfamily. SWISS: Q9Y5B9 Gene ID: 11198 Database links: Entrez Gene: 514989 Cow Entrez Gene: 612874 Dog Entrez Gene: 11198 Human Entrez Gene: 114741 Mouse Entrez Gene: 305851 Rat Omim: 605012 Human SwissProt: E1BNP8 Cow SwissProt: Q9Y5B9 Human SwissProt: Q920B9 Mouse Unigene: 213724 Human Unigene: 21662 Mouse Unigene: 93187 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Placenta (Mouse) Lysate at 40 ug Primary: Anti-SUPT16H (bs-7879R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 120 kD Observed band size: 120 kD  Paraformaldehyde-fixed, paraffin embedded (Mouse colon); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (SUPT16H) Polyclonal Antibody, Unconjugated (bs-7879R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining. |
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文献和实验人相比，他样血清IgE明显升高，肥大细胞数较多而且胞膜上IgE受体也较多。家系调查表明，特应症由常染色体显性遗传，但同一家系中不同成员所患的特应症可以不同。他们产生高IgE抗体的能力可能与组织相容性复合体Ⅱ类（MHC ClassⅡ）中的某些特殊位点有关。有报道反指出，屋尘螨特异性CD4+T细胞克隆对螨的应答受HLA-DRAB1和HLA-DRAB3基因产物的限制，说明这些基因产物在T细胞识别变应原中具有重要的功能。 2．接触变应原的机会接触变应原的机会是特异性IgE抗体水平高低的重要
子才能发挥作用，没有启动子存在，增强子不能表现活性。但增强子对动子没有严格的专一性，同一增强子可以影响不同类型启动子的转录。例如当含有增强子的病毒 基因组 整合入宿主细胞基因组时，能够增强整合区附近宿主某些基因的转录；当增强子随某些染色体段落移位时，也能提高移到的新位置周围基因的转录。使某些癌基因转录表达增强，可能是肿瘤发生的因素之一。 ④增强子的作用机理虽然还不明确，但与其他顺式调控元件一样，必须与特定的蛋白质因结合后才能发挥增强转录的作用。增强子一般具有组织
和报告分子与标记微球反应，样品中的目的分子（待检测的抗原或抗体、生物素标记的靶核酸片段、酶等）能够与探针和报告分子特异性结合，使交联探针的微球携带上报告分子藻红蛋白，随后利用仪器（如Luminex 100）对微球进行检测和结果分析。Luminex 100采用微流技术使微球快速单列通过检测通道，并使用红色和绿色两种激光分别对单个微球上的分类荧光和报告分子上的报告荧光进行检测。红色激光可将微球分类，从而鉴定各个不同的反应类型（即定性）；绿色激光可确定微球上结合的报告荧光分子的数量，从而确定微球上结合
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