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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-6968R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
HLA DM
- 抗体名:
组织相容性复合体α抗体
- 宿主:
Rabbit
- 适应物种:
Human, Mouse, Rat, Dog, Pig, Cow, Horse,
- 免疫原:
KLH conjugated synthetic peptide derived from human HLA DM:101-200/261
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | HLA DM |
| 中文名称 | 组织相容性复合体α抗体 |
| 别 名 | Class II histocompatibility antigen M alpha chain; D6S222E; DMA; HLA class II histocompatibility antigen DM alpha chain; HLA DMA; HLADM; Major histocompatibility complex class II DM alpha; MHC class II antigen DMA; Really interesting new gene 6 protein; Ring 6; Ring6; DMA_HUMAN. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 26kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human HLA DM:101-200/261 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Human Leukocyte Antigens are highly polymorphic proteins that are involved in the presentation of antigens to the T-cell receptor. There are two classes of HLA antigens, class I (HLA-A, HLA-B and HLA-C) and class II (HLA-D). This antibody can be used for HLA typing. HLA DM plays a critical role in catalyzing the release of class II HLA-associated invariant chain-derived peptides (CLIP) from newly synthesized class II HLA molecules and freeing the peptide binding site for acquisition of antigenic peptides. Subunit: Heterodimer of an alpha chain (DMA) and a beta chain (DMB). Subcellular Location: Late endosome membrane; Single-pass type I membrane protein. Lysosome membrane; Single-pass type I membrane protein. Similarity: Belongs to the MHC class II family. Contains 1 Ig-like C1-type (immunoglobulin-like) domain. SWISS: P28067 Gene ID: 3108 Database links: UniProtKB/Swiss-Prot: P28067.1 Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 | ![]() Sample: Lung (Mouse) Lysate at 40 ug Primary: Anti-HLA DM (bs-6968R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 26 kD Observed band size: 26 kD |
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文献和实验人类主要组织相容性复合体 HLA HLA(human leucocyte antigen)基因系统是人类主要组织相容性复合体。人类第一个HLA抗原由法国Dausset在1958年从三个多次接受输血患者的血清中检出,当时命名为MAC,相当于目前正式命名的HlA―A2加上HLA―A28。基因产物称为HLA抗原或白细胞抗原。有关HlA的研究工作在临床器官移植配型和国际大协作推动下发展十分迅速,涉及的范围已远远超出了器官移植配型,成为免疫学、遗传学及人类
组织相容性抗原(histocompatibility antigen): 通过移植鉴定与组织相容性有关的抗原。(机体参与排斥反应的抗原系统多达20个以上) 主要组织相容性抗原系统(major histocompatibility antigen system, MHS): 能引起较强移植排斥反应的抗原。(较弱-minor) 主要组织相容性复合体(major histocompatibility complex, MHC): 编码主要组织
主要组织相容性复合体 (major histocompatibility complex, MHC):简称MHC,是脊椎动物中的一组紧密连锁的基因构成的复合座位,包括为一些细胞表面抗原编码的以及为血清补体成分编码的基因,它们控制着机体的免疫应答和疾病易感性。MHC有高度遗传多态性,与器官移植和疾病遗传有密切关系,还可作为良好的遗传标志用于群体演化的研究
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