- ¥1380 - 2200
- LMAI Bio
- LM-6248R
- 进口/国产
- 2025年12月26日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6248R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
IMPAD1
- 抗体名：
肌醇单磷酸酶IMPA3抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human IMPAD1:81-180/359
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | IMPAD1 |
| 中文名称 | 肌醇单磷酸酶IMPA3抗体 |
| 别 名 | IMP 3; IMPA3; IMPase 3; Inositol monophosphatase domain containing protein 1; Myo inositol monophosphatase A3. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 肿瘤 心血管 信号转导 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞浆 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human IMPAD1:81-180/359 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene encodes a member of the inositol monophosphatase family. The encoded protein is localized to the Golgi apparatus and catalyzes the hydrolysis of phosphoadenosine phosphate (PAP) to adenosine monophosphate (AMP). Mutations in this gene are a cause of GRAPP type chondrodysplasia with joint dislocations, and a pseudogene of this gene is located on the long arm of chromosome 1. Function: May play a role in the formation of skeletal elements derived through endochondral ossification, possibly by clearing adenosine 3',5'-bisphosphate produced by Golgi sulfotransferases during glycosaminoglycan sulfation Subcellular Location: Golgi apparatus, trans-Golgi network membrane; Single-pass type II membrane protein. Post-translational modifications: Contains N-linked glycan resistant to endoglycosydase H. DISEASE: Defects in IMPAD1 are the cause of chondrodysplasia with joint dislocations GPAPP type (CDP-GPAPP) [MIM:614078]. A condition consisting of congenital joint dislocations, chondrodysplasia with short stature, micrognathia and cleft palate, and a distinctive face. Similarity: Belongs to the inositol monophosphatase family. SWISS: Q9NX62 Gene ID: 54928 Database links: Entrez Gene: 54928 Human Entrez Gene: 242291 Mouse Entrez Gene: 103689950 Rat Entrez Gene: 312952 Rat Omim: 614010 Human SwissProt: Q9NX62 Human SwissProt: Q80V26 Mouse SwissProt: D4AD37 Rat Unigene: 438689 Human Unigene: 218889 Mouse Unigene: 369779 Mouse Unigene: 65720 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Muscle(Mouse) (Mouse) Lysate at 40 ug Primary: Anti-IMPAD1 (bs-6248R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 39 kD Observed band size: 39 kD |
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文献和实验的研究方法正常培养的细胞自噬活性很低，不适于观察，因此，必须对自噬进行人工干预和调节，经报道的工具药有： 1. 自噬诱导剂 Bredeldin A / Thapsigargin / Tunicamycin ：模拟内质网应激 Carbamazepine/ L-690，330/ Lithium Chloride（氯化锂）：IMPase 抑制剂（即 Inositol monophosphatase，肌醇单磷酸酶） Earle's 平衡盐溶液：制造饥饿 N-Acetyl-D
正常培养的细胞自噬活性很低，不适于观察，因此，必须对自噬进行人工干预和调节，经报道的工具药有： 一、自噬诱导剂 (1) Bredeldin A / Thapsigargin / Tunicamycin ：模拟内质网应激 (2) Carbamazepine/ L-690，330/ Lithium Chloride（氯化锂）：IMPase 抑制剂（即Inositol monophosphatase，肌醇单磷酸酶） (3) Earle's平衡盐溶液：制造饥饿
化锂）：IMPase 抑制剂（即Inositol monophosphatase，肌醇单磷酸酶） 3）Earle's平衡盐溶液：制造饥饿 4）N-Acetyl-D-sphingosine（C2-ceramide）：Class I PI3K Pathway抑制剂 5）Rapamycin：mTOR抑制剂 6）Xestospongin B/C：IP3R阻滞剂 （二）自噬抑制剂 1）3-Methyladenine（3-MA）：（Class III PI3K） hVps
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