- ¥780 - 2200
- LMAI Bio
- LM-6184R
- 进口/国产
- 2026年01月19日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Horse,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6184R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Renin
- 抗体名：
肾素/血管紧张素形成酶Ren1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Horse,
- 免疫原：
KLH conjugated synthetic peptide derived from human Renin:331-406/406
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
| 英文名称 | Renin |
| 中文名称 | 肾素/血管紧张素形成酶Ren1抗体 |
| 别 名 | Angiotensin forming enzyme; Angiotensin forming enzyme precursor; Angiotensinogenase; Angiotensinogenase precursor; HNFJ2; REN; Renin1; Renin-1; Renin 1; Ren1; RENI_HUMAN; Renin; Renin precursor renal. |
 |
Specific References (2) | bs-6184R has been referenced in 2 publications. [IF=1.92] Liu, Chen, et al. "Pulmonary artery denervation improves pulmonary arterial hypertension induced right ventricular dysfunction by modulating the local renin-angiotensin-aldosterone system." BMC Cardiovascular Disorders 16.1 (2016): 192. WB ; Dog. PubMed:27724864 [IF=5.11] Wanka, Heike, et al. "Anti-necrotic and cardioprotective effects of a cytosolic renin isoform under ischemia-related conditions." Journal of Molecular Medicine(2015): 1-9. WB ; Rat. PubMed:26256830 |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 染色质和核信号 信号转导 转录调节因子 激酶和磷酸酶 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 37kDa |
| 细胞定位 | 细胞膜 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Renin:331-406/406 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]. Function: Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Subunit: Interacts with ATP6AP2. Subcellular Location: Secreted. Membrane. Associated to membranes via binding to ATP6AP2. DISEASE: Defects in REN are the cause of familial juvenile hyperuricemic nephropathy type 2 (HNFJ2) [MIM:613092]. It is a renal disease characterized by juvenile onset of hyperuricemia, slowly progressive renal failure and anemia. Similarity: Belongs to the peptidase A1 family. SWISS: P00797 Gene ID: 5972 Database links: Entrez Gene: 469651 Chimpanzee Entrez Gene: 5972 Human Entrez Gene: 19701 Mouse Entrez Gene: 19702 Mouse Entrez Gene: 24715 Rat Omim: 179820 Human SwissProt: P60016 Chimpanzee SwissProt: Q6DLS0 Cynomolgus Monkey SwissProt: P00797 Human SwissProt: P00796 Mouse SwissProt: P06281 Mouse SwissProt: P08424 Rat Unigene: 3210 Human Unigene: 220955 Mouse Unigene: 9831 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验（angiotensin Ⅱ）；血管紧张素Ⅱ在血管紧张素酶A的作用下，分解而形成血管紧张素Ⅲ（angiotensin Ⅲ）。血管紧张Ⅱ、Ⅲ均具有明显的生理效应，主要具有收缩血管（血管紧张素Ⅱ＞血管紧张素Ⅲ）和促进肾上腺皮质分泌醛固酮（血管紧张素Ⅲ＞血管紧张素Ⅱ）的作用。血管紧张素Ⅱ、Ⅲ除可被靶细胞摄取外，主要为血浆中血管紧张分解酶所灭活。在休克、脱水等肾前性因素作用时，肾素-血管紧张素-醛固酮系统活性即可增加，从而可提高平均动脉压，促进钠水潴留，因而具有代偿意义。但如血管紧张素形成过多，作用延续过久，则也可因肾脏
肾素由近球细胞分泌。全身平均动脉压降低、脱水、肾动脉狭窄、低钠血症、交感神经紧张性增高等，可分别通过对入球小动脉壁牵张感受器、致密斑钠受体，以及直接对近球细胞的作用而引起肾素释放增多。肾素进入血液循环后，即使由肝细胞生成的血管紧张素原（angiotensinogen,一种α 2 -球蛋白）分解成为血管紧张素Ⅰ（angiotensin Ⅰ）；后者在转化酶的作用下形成血管紧张素Ⅱ（angiotensin Ⅱ）；血管紧张素Ⅱ在血管紧张素酶A的作用下，分解而形成血管紧张素Ⅲ
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