Sabutoclax,1228108-65-3

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Sabutoclax

CAS No. : 1228108-65-3

MCE 国际站：Sabutoclax

产品活性：Sabutoclax 是有效的 Bcl-2 Family (Bcl-2, Bcl-XL, Mcl-1, Bfl-1) 抑制剂， IC₅₀ 值分别为 0.32 μM， 0.31 μM， 0.20 μM， 0.62 μM。Sabutoclax 提高 Bax、Bim、PUMA 和 survivin 的表达。

研究领域：Apoptosis

作用靶点：Bcl-2 Family

In Vitro: Sabutoclax (0.001-10 μM; 72 h) potentially inhibits cell growth of human prostate cancer, lung cancer cell line.
Sabutoclax (0.01 μM-1 μM; 24-48 h) potentially induces cell apoptosis in human diffuse large B-cell lymphoma cell line.
Sabutoclax (0 μM-15 μM; 48 h) uptrgulates the level of pro-apoptotic proteins in chemoresistent cells.

In Vivo: Sabutoclax (1-5 mg/kg; i.p.; every two days in 18 D) reduces tumor growth in M2182-bearing athymic nude mice.

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