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- MedChemExpress(MCE)
- 美国
- HY-112181
- 2025年12月05日
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- 保存条件：
4°C, protect from light
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
1695533-89-1
- 规格：
10 mM * 1 mL/1 mg/5 mg/10 mg/25 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1438.0 |
|---|---|---|---|
| 规格： | 1 mg | 产品价格： | ￥871.0 |
| 规格： | 5 mg | 产品价格： | ￥1839.0 |
| 规格： | 10 mg | 产品价格： | ￥2758.0 |
| 规格： | 25 mg | 产品价格： | ￥4690.0 |
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KO-947
CAS No. : 1695533-89-1
MCE 国际站：KO-947
产品活性：KO-947是有效和选择性的 ERK1/2 激酶抑制剂，在MAPK途径失调的肿瘤中具有潜在效用。
研究领域：MAPK/ERK Pathway | Stem Cell/Wnt
作用靶点：ERK
In Vitro: KO-947 is a 10 nM inhibitor of ERK with at least 50-fold selectivity against a panel of 450 kinases. KO-947 blocks ERK signaling and proliferation of tumor cells exhibiting dysregulation of MAPK pathway signaling, including mutations in BRAF, NRAS or KRAS, at low nanomolar concentrations.
In Vivo: In cell-line derived xenograft studies, KO-947 profoundly suppresses ERK signaling for up to five days after a single dose and induces regressions in RAS- and RAF-mutant melanoma, NSCLC and pancreatic cancer models on administration schedules ranging from daily to weekly. Intermittent dosing enables comparable antitumor activity at reduced dose-intensity.
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