- ￥1720 - 2780
- MedChemExpress(MCE)
- 美国
- HY-100487
- 2026年07月16日
企业认证
相关产品推荐更多 >
万千商家帮你免费找货
0 人在求购买到急需产品
相关阅读
AI 赋能培养基定制开发：CHO 培养基是如何实现产量提升Cytoscape 教程来了！快速实现顶刊同款通路网络图五大应用案例：Mustang Q 膜层析应用全解析1 个小工具，一次性搞定流程图、质粒图谱和信号通路图- 详细信息
- 文献和实验
- 技术资料
- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years. In solvent: -80°C, 6 months; -20°C, 1 month.
- 英文名：
MLN7243
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- 规格：
10 mM * 1 mL/5 mg/10 mg
| 规格： | 10 mM * 1 mL | 产品价格： | ￥1892.0 |
|---|---|---|---|
| 规格： | 5 mg | 产品价格： | ￥1720.0 |
| 规格： | 10 mg | 产品价格： | ￥2780.0 |
MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务。
TAK-243
CAS No. : 1450833-55-2
MCE 国际站：TAK-243
产品活性：TAK-243 (MLN7243) 是一种首创的，选择性的泛素激活酶，UAE (UBA1) 抑制剂 (IC50=1 nM)，其阻断了泛素结合，破坏了单泛素信号传导和全蛋白泛素化。TAK-243 (MLN7243) 诱导内质网应激 (ERS) 反应，消除 NF-κB 通路活化，促进细胞凋亡。
研究领域：Metabolic Enzyme/Protease | NF-κB | Apoptosis
作用靶点：E1/E2/E3 Enzyme | NF-κB | Apoptosis
In Vitro: TAK-243 shows anti-proliferative effect on a panel of cell lines derived from hematologic and solid tumors with variable EC50 values that ranged from 0.006 μM to 1.31 μM.
?TAK-243 reduces growth and viability of human AML cell lines (OCI-AML2, TEX, U937 and NB4) in a concentration- and time-dependent manner with IC50s ranging from 15-40 nM after treatment for 48 hours.
In Vivo: TAK-243 significantly delays tumor growth in mice (T/C=0.02) with no toxicity as evidenced by no changes in mouse body weight, serum chemistry, or organ histology. TAK-243 reduces primary AML tumor burden in both tested samples without toxicity.
相关产品：Clinical Compound Library Plus | Bioactive Compound Library Plus | Apoptosis Compound Library | Immunology/Inflammation Compound Library | Metabolism/Protease Compound Library | NF-κB Signaling Compound Library | Stem Cell Signaling Compound Library | Anti-Cancer Compound Library | Clinical Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Differentiation Inducing Compound Library | Oxygen Sensing Compound Library | Ubiquitination Compound Library | Endoplasmic Reticulum Stress Compound Library | Pyroptosis Compound Library | Chemical Probe Library | Anti-Breast Cancer Compound Library | Anti-Pancreatic Cancer Compound Library | Anti-Blood Cancer Compound Library | Anti-Cancer Metabolism Compound Library | Anti-Obesity Compound Library | Transcription Factor-Targeted Library | Anti-Liver Cancer Compound Library | Antidepressant Compound Library | Anti-Prostate Cancer Compound Library | Cancer Stem Cells Compound Library | Heterocyclic Compound Library | Pain-Related Compound Library | Highly Selective Inhibitors Library | Highly Selective Activators Library | Cell Death Library | MG-132 | Phorbol 12-myristate 13-acetate | Doxorubicin hydrochloride | Bafilomycin A1 | LY294002 | Tamoxifen | Paclitaxel | Y-27632 | Acetylcysteine | Angiotensin II human | 2-Deoxy-D-glucose | Staurosporine | SB-431542 | Actinomycin D | Deferoxamine mesylate | Bortezomib | 5-Fluorouracil | Trametinib | Sorafenib | Oxaliplatin | Gemcitabine | Temozolomide | Rotenone | Mdivi-1 | Elesclomol | Ruxolitinib | Decitabine | SP600125 | MK-2206 dihydrochloride | Etoposide
热门产品线：重组蛋白 | 化合物库 | 天然产物 | 荧光染料 | PROTAC | 同位素标记物
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Dye Reagents | PROTAC | Isotope-Labeled Compounds
风险提示：丁香通仅作为第三方平台，为商家信息发布提供平台空间。用户咨询产品时请注意保护个人信息及财产安全，合理判断，谨慎选购商品，商家和用户对交易行为负责。对于医疗器械类产品，请先查证核实企业经营资质和医疗器械产品注册证情况。
文献和实验Cenicriviroc Mesylate (TAK652),497223-28-6拮抗剂的全面介绍
Cenicriviroc Mesylate（甲磺酸西尼替洛韦，研发代号TAK-652）是一款高活性、双靶点的CCR2/CCR5特异性拮抗剂，兼具优异的抗病毒与抗炎活性，是炎症性疾病及艾滋病病毒感染相关科研领域的核心工具化合物。该产品由知名生命科学试剂品牌MedChemExpress (MCE) 提供，货号HY-14882A，凭借精准的靶点抑制能力、明确的药理机制及丰富的科研验证数据，被广泛应用于纤维化疾病、HIV病毒感染机制及抗炎药理的深度研究，目前已有7篇相关科研文献引用该产品开展试验
Cell Metab：西京医院王琳教授团队报道非酒精性脂肪肝炎新靶点
Metabolism 上在线发表了题为 Tripartite motif 16 ameliorates nonalcoholic steatohepatitis by promoting the degradation of phospho-TAK1 的研究成果 (4)。该研究发现 E3 泛素连接酶 TRIM16 通过促进 p-TAK1 的泛素化依赖性降解，改善 NASH 进展过程中的脂质积累和炎症。 图片来源：Cell Metabolism研究内容肝细胞的脂肪毒性诱导 TRIM16 的表达脂肪毒性是脂质过度积累
Smads, TAK1, and Their Common Target ATF-2 Play a Critical Role in Cardiomyocyte Differentiation We previously demonstrated that bone morphogenetic proteins (BMPs) induce cardiomyocyte differentiation through the mitogen-activated protein kinase
技术资料暂无技术资料 索取技术资料
