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- 2025年12月05日
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- 保存条件：
Powder: -20°C, 3 years; 4°C, 2 years.In solvent: -80°C, 6 months; -20°C, 1 month.
- 库存：
货期：1-2天
- 供应商：
MedChemExpress LLC
- CAS号：
925434-55-5
- 规格：
5 mg/10 mg/25 mg/50 mg/100 mg
| 规格： | 5 mg | 产品价格： | ￥997.0 |
|---|---|---|---|
| 规格： | 10 mg | 产品价格： | ￥1595.0 |
| 规格： | 25 mg | 产品价格： | ￥2999.0 |
| 规格： | 50 mg | 产品价格： | ￥4200.0 |
| 规格： | 100 mg | 产品价格： | ￥5460.0 |
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SRT 1720
CAS No. : 925434-55-5
MCE 国际站：SRT 1720
产品活性：SRT 1720 是人 SIRT1 的有效激活剂，EC1.5 值为 0.16 μM，对 SIRT2 和 SIRT3 的作用较弱，EC1.5 值分别为 37 μM 和 > 300 μM。
研究领域：Cell Cycle/DNA Damage | Epigenetics | Autophagy
In Vitro: SRT 1720 effectively decreases the acetylation of p53 in cells even in the absence of SIRT1, and this is attributed to inhibition of histone acetyltransferase p300.
In Vivo: SRT 1720 (10, 30, 100 mg/kg, p.o.) significantly reduces the hyperinsulinaemia after 4 weeks, partially normalizing elevated insulin levels similar to rosiglitazone treatment. SRT 1720 treatment significantly reduces fasting blood glucose to near normal levels in Lepob/ob mice. SRT 1720 has ability to protect against the negative effects of diet-induced obesity in mice, and has a connection to metabolic adaptation in fatty acid and oxidative metabolism through downstream targets of SIRT1 such as PGC1α and FOXO1. SRT 1720 (50-100 mg/kg, p.o.), during emphysema development attenuates elastase-induced airspace enlargement and lung function impairment as well as reduces arterial oxygen saturation in WT mice.
相关产品：Bioactive Compound Library Plus | Cell Cycle/DNA Damage Compound Library | Epigenetics Compound Library | Histone Modification Research Compound Library | Autophagy Compound Library | Anti-Aging Compound Library | Antioxidant Compound Library | Anti-diabetic Compound Library | Oxygen Sensing Compound Library | Glutamine Metabolism Compound Library | Anti-Obesity Compound Library | Human Metabolite Library | Heterocyclic Compound Library | Highly Selective Activators Library | Cell Death Library | Nicotinamide | Resveratrol | Selisistat | 3-TYP | Nicotinamide riboside chloride | Fisetin | OSS_128167 | Suramin sodium salt | SRT 1720 monohydrochloride | UBCS039 | AGK2 | Sirtinol | SRT 2104 | SIRT7 inhibitor 97491 | Thiomyristoyl | Tenovin-6 | MC3482 | SirReal2 | Cambinol | SRT 2183 | Ganoderic acid D | SIRT5 inhibitor 1 | SRT 1460 | AK-7 | Agrimol B | CAY10602 | SIRT-IN-3 | ADTL-SA1215 | Perindopril erbumine | Tenovin-1
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文献和实验loops by gene mutation enhances SRT synthesis. We demonstrate that gene loop conformation enforces transcriptional directionality on otherwise bidirectional promoters.
花香蝶自来|Solarbio小分子化合物“优秀员工展”第二十五期
149733-79-9 溶解度 Soluble in Water 生物 活性 Lucifer Yellow Cadaverine 可以标记细胞中的内吞噬泡。Ex/Em=428/536 nm。 应用案例 Tao Q, et al. Int J Mol Sci. 2023 Dec 13;24(24):17434. 油红O CAT IO1720 CAS 1320-06-5 溶解度 Soluble
μL 体系 2× MasterMix 25 μL 上游 Primer （ 10 μM 1-5 μL 下游 Primer （ 10 μM ） 1-5 μL 模板 lamid DNA ～ 50 ng genomic DNA ～ 1000 ng cDNA ～ 500 ng 粗提液 ～ 2 μL 灭菌蒸馏水至 50 μL PCR 扩增实例： 一、plasmid DNA 扩增 1．提取的质粒 DNA 扩增 以pUC19 质粒为模板扩增 100，250，500
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