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- 详细信息
- 文献和实验
- 技术资料
- 供应商:
上海联迈生物工程有限公司
- 库存:
大量
- 目录编号:
LM-20841R
- 克隆性:
多克隆
- 抗原来源:
Rabbit
- 保质期:
1年
- 抗体英文名:
CCL27
- 抗体名:
皮肤T细胞虏获趋化因子抗体
- 宿主:
Rabbit
- 适应物种:
Mouse, Rat,
- 免疫原:
KLH conjugated synthetic peptide derived from mouse CCL27:26-100/120
- 亚型:
IgG
- 形态:
Lyophilized or Liquid
- 应用范围:
ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复)
- 浓度:
1mg/ml
- 保存条件:
Store at -20 °C
- 规格:
100ul 200ul
| 英文名称 | CCL27 |
| 中文名称 | 皮肤T细胞虏获趋化因子抗体 |
| 别 名 | ALP; CTACK; C-C motif chemokine 27; CC chemokine ILC; Ccl27; CTAK; Cutaneous T cell attracting chemokine; Cutaneous T-cell-attracting chemokine; ESkine; IL 11 R alpha locus chemokine; IL-11 R-alpha-locus chemokine; PESKY; SCYA27; Skinkine; Small inducible cytokine A27; Small-inducible cytokine A27. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 免疫学 趋化因子 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Mouse, Rat, |
| 产品应用 | ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 (石蜡切片需做抗原修复) not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 19kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from mouse CCL27:26-100/120 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: This gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene is chemotactic for skin-associated memory T lymphocytes. This cytokine may also play a role in mediating homing of lymphocytes to cutaneous sites. It specifically binds to chemokine receptor 10 (CCR10). Studies of a similar murine protein indicate that these protein-receptor interactions have a pivotal role in T cell-mediated skin inflammation. [provided by RefSeq]. Function: Chemotactic factor that attracts skin-associated memory T-lymphocytes. May play a role in mediating homing of lymphocytes to cutaneous sites. Binds to CCR10. Subunit: Monomer, dimer, and tetramer. Heparin avidly promotes oligomerization. Subcellular Location: Secreted. Tissue Specificity: Testis, thymus, placenta, ovary and skin. Similarity: Belongs to the intercrine beta (chemokine CC) family. SWISS: Q9Z1X0 Gene ID: 20301 Database links: Entrez Gene: 100039863 Mouse Entrez Gene: 100039939 Mouse Entrez Gene: 100040048 Mouse Entrez Gene: 20301 Mouse Entrez Gene: 362505 Rat SwissProt: Q9Z1X0 Mouse Unigene: 335946 Mouse Unigene: 425176 Mouse Unigene: 484274 Mouse Unigene: 6660 Mouse Unigene: 78371 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. CCL27是一种CC型趋化因子,又被称为Skinkine,ESkine和CTACK。CCL27基因位于人类染色体9,它与皮肤上归巢的记忆T淋巴细胞有关,并在T细胞介导的皮肤炎症中起着重要的作用。CCL27表达在许多组织,包括性腺,胸腺,胎盘和皮肤。其配体为CCR10,CCL27与接触性软疣病毒编码产生的蛋白质MC148有较高的同源性,但却与人疱疹病毒8型编码产生病毒巨噬细胞炎症蛋白-Ⅱ竞争结合受体CCR10。 |
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文献和实验趋化因子。这些细胞因子和趋化因子通过吸引CD4T细胞和单核细胞向损伤部位迁移、诱导MqD成熟和吸引更多的T细胞等方式增强炎症应答。角质形成细胞参与构成表皮结构的完整性,在表皮免疫学中发挥着重要作用。 身体中的很多部分都可发生Ⅳ型超敏反应。常见的有:出现特异性皮炎的皮肤、结核病患者的肺部、过敏性肺炎、Wegener肉芽肿、l型糖尿病(胰岛素依赖性糖尿病)的胰腺以及发生甲状腺炎症的甲状腺。
和脾脏中表达,外周血中几乎不表达。CCR8诱导趋化单核细胞和Th2型淋巴细胞。CCR9高表达于成熟和不成熟的胸腺细胞,而在脾脏和淋巴结中表达低,显示出它与T细胞发育不可分割的联系。人的CCRlo在睾丸和小肠高表达,鼠的CCRl0则在小肠、结肠、淋巴结和派氏集合淋巴结高表达,胸腺和脾表达量低。CCRl0不仅参与炎症反应,而且对于皮肤、内皮组织和黏膜系统的生理自体调节意义重大。CCRl5基因位于人染色体3q22,主要表达于心脏、小肠和肺等组织。 3.XCR趋化因子 Lymphotactin
病原体表达的或病原体刺激组织细胞表达的趋化因子所感应,吞噬细胞借趋化因子受体遵循趋化因子的浓度梯度向感染灶定向移动。活化后的吞噬细胞可经受体介导等方式包裹病原体形成吞噬体,吞噬体与溶酶体融合形成吞噬溶酶体,再通过氧依赖途径和氧非依赖途径杀菌。 NK细胞可非特异性杀伤某些病毒和胞内感染病原体,类似于适应性免疫中的效应CTL,通过穿孔素-颗粒酶机制和ADCC发挥细胞毒作用。NK细胞的细胞毒功能在某些病原体感染情况下,可替代T细胞杀伤效应。NK细胞活化后分泌IFN-y,可促进Mc活化分泌IL
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