- ¥1380 - 2200
- LMAI Bio
- LM-19990R
- 进口/国产
- 2025年07月10日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-19990R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PPP1R16B
- 抗体名：
蛋白磷酸酶1调节亚基抑制蛋白16B抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human PPP1R16B:301-400/567
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PPP1R16B |
| 中文名称 | 蛋白磷酸酶1调节亚基抑制蛋白16B抗体 |
| 别 名 | ANKRD4; Ankyrin repeat domain containing protein 4; ankyrin repeat domain protein 4; Ankyrin repeat domain-containing protein 4; CAAX box protein TIMAP; hTIMAP; KIAA0823; PP16B_HUMAN; PPP1R16B; Protein phosphatase 1 regulatory inhibitor subunit 16B; protein phosphatase 1, regulatory (inhibitor) subunit 16B; TGF beta inhibited membrane associated protein; TGF-beta-inhibited membrane-associated protein; TIMAP. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 64kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PPP1R16B:301-400/567 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] Function: Regulator of protein phosphatase 1 (PP1) that acts as a positive regulator of pulmonary endothelial cell (EC) barrier function. Involved in PKA-mediated moesin dephosphorylation which is important in EC barrier protection against thrombin stimulation. Promotes the interaction of PPP1CA with RPSA/LAMR1 and in turn facilitates the dephosphorylation of RPSA/LAMR1. Involved in the regulation of endothelial cell filopodia extension. May be a downstream target for TGF-beta1 signaling cascade in endothelial cells. Subcellular Location: Cell membrane. Cell membrane. Nucleus. Co-localizes with RPSA/LAMR1 in the cell membrane. Tissue Specificity: Highly expressed in vascular endothelium, CNS, lung, spleen, kidney and testis. Post-translational modifications: Phosphorylated by PKA and, after PKA priming, by GSK3B. Phosphorylation by GSK3B reduces its association with PP1C and enhances PP1C activity. Dephosphorylation by its associated PP1C results in enhanced association with PP1C, but reduced PP1C activity. Similarity: Contains 5 ANK repeats. SWISS: Q96T49 Gene ID: 26051 Database links: Entrez Gene: 26051 Human Entrez Gene: 228852 Mouse Omim: 613275 Human SwissProt: Q96T49 Human SwissProt: Q8VHQ3 Mouse Unigene: 45719 Human Unigene: 150540 Mouse Unigene: 485085 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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文献和实验性。生长因子受体可以通过Ras激活催化亚基。P13K激活的结果是使嵌合在细胞膜上的磷脂酰肌醇二磷酸(PIP2)磷酸化生成磷脂腺肌醇三磷酸(PIPa)。PIP3作为第二信使，募集含PH结构域的蛋白质到细胞内膜。Akt(蛋白激酶B)含有PH结构域的丝氨酸／苏氨酸激酶之一。Akt除了氨基端的PH结构域外，还有一个中央催化结构域和羧基端调节结构域。Akt家族有3个成员：Aktl、Akt2和Akt3。3个成员在组织分布和功能方面大同小异。Akt被PIP3吸引到细胞膜内侧后，还要在Thr308和Ser473位点
不具有吸附穿入作用的病毒表面抗原及病毒颗粒内部抗原所诱生的抗体，称之为非中和抗体。如抗流感病毒神经氨酸酶的抗体，不能阻止病毒吸附穿放敏感细胞，但可与病毒表面神经氨酸酶结合，易被吞噬清除；抗流感病毒核蛋白的抗体，没有免疫保护作用。 （二）抗体介导的抗病毒作用方式 1．中和抗体和病毒表面抗原结合，导致病毒表面蛋白质构型的改变，阻止其吸附于敏感细胞。中和作用是机体灭活游离病毒的主要方式。 2．病毒表面抗原（如流感病毒的血凝素和神经氨酸酶）与相应的抗体（中和抗体或非中和抗体
质组是动态的，随着大量刺激的变化而变化，翻译后修饰常用于调节细胞活性。PTM 发生在不同的氨基酸侧链或肽键上，它们通常由酶活性介导。事实上，据估计，5% 的蛋白质组包含 200 多种类型翻译后修饰的酶。这些酶包括激酶、磷酸酶、转移酶和连接酶，它们在氨基酸侧链上添加或移除功能组、蛋白质、脂质或糖；以及蛋白酶，它们切割肽键以移除特定序列或调节亚基。许多蛋白质也可以利用自催化结构域，如自激酶和自蛋白分解结构域进行自我修饰。翻译后修饰可以发生在蛋白质生命周期的任何阶段。例如，许多蛋白质在翻译完成后不久就被修饰
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