- ¥1380 - 2200
- LMAI Bio
- LM-19580R
- 进口/国产
- 2026年01月15日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Pig, Horse, Rabbit,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-19580R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PSTPIP2
- 抗体名：
脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Pig, Horse, Rabbit,
- 免疫原：
KLH conjugated synthetic peptide derived from human PSTPIP2:131-230/334
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PSTPIP2 |
| 中文名称 | 脯氨酸-丝氨酸-苏氨酸磷酸酶相互作用蛋白2抗体 |
| 别 名 | Macrophage actin associated tyrosine phosphorylated protein; Macrophage actin-associated tyrosine-phosphorylated protein; MAYP; PPIP2_HUMAN; Proline serine threonine phosphatase interacting protein 2; Proline-serine-threonine phosphatase-interacting protein 2. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 信号转导 结合蛋白 细胞骨架 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Pig, Horse, Rabbit, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 39kDa |
| 细胞定位 | 细胞膜 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PSTPIP2:131-230/334 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | Function: Binds to F-actin. May be involved in regulation of the actin cytoskeleton (By similarity). Subunit: Homodimer (PubMed:19584923). Homotrimer PubMed:17964261). Interacts (via coiled-coil domain) with CD2AP, PTPN12 and PTPN18. Interacts (via SH3 domain) with ABL1 and WAS. Interacts (via SH3 and coiled-coil domains) with MEFV (via B-box zinc finger); the interaction allows binding of MEFV to PYCARD and facilitates formation of PYCARD pyroptosomes. Interacts with CD2, DNM2 and FASLG. Subcellular Location: Cell Membrane; peripheral membrane protein and Cytoplasmic (by similarity). Tissue Specificity: Highly expressed in the peripheral blood leukocytes, granulocytes and monocytes, namely in T-cells and natural killer cells, and in spleen. Weakly expressed in the thymus, small intestine, lung and placenta. Post-translational modifications: Dephosphorylated on Tyr-345 by PTPN18, this event negatively regulates the association of PSTPIP1 with SH2 domain-containing proteins as tyrosine kinase. Phosphorylation of Tyr-345 is probably required for subsequent phosphorylation at other tyrosine residues. Phosphorylation is induced by activation of the EGFR and PDGFR in a ABL1 dependent manner. The phosphorylation regulates the interaction with WAS and with MEFV (By similarity). DISEASE: PAPA syndrome (PAPAS) [MIM:604416]: Characterized by autosomal dominant inheritance of early-onset, primarily affecting skin and joint tissues. Recurring inflammatory episodes lead to accumulation of sterile, pyogenic, neutrophil-rich material within the affected joints, ultimately resulting in significant destruction. Similarity: Contains 1 F-BAR domain. Contains 1 SH3 domain. SWISS: Q9H939 Gene ID: 9050 Database links: Entrez Gene: 9050 Human Entrez Gene: 19201 Mouse Entrez Gene: 307248 Rat SwissProt: Q9H939 Human SwissProt: Q99M15 Mouse Unigene: 567384 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Paraformaldehyde-fixed, paraffin embedded (rat uterus tissue); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PSTPIP2) Polyclonal Antibody, Unconjugated (bs-19580R) at 1:400 overnight at 4°C, followed by a conjugated secondary (sp-0023) for 20 minutes and DAB staining. |
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文献和实验密码子的简并性； (4)密码子的通用性，所有生物从最低等的病毒直至人类，蛋白质合成都使用同一套密码子表(表15-8)，仅有极少的例外，如特殊细胞器线粒体，叶绿体所用的密码稍有不同。(表15-9)。� 表15-8 通用遗传密码及相应的氨基酸 第一个核苷酸5′ 第二个核苷酸 第三个核苷酸3′ U C A G U 苯丙氨酸 丝氨酸 酪氨酸 半胱氨酸 U 苯丙氨酸 丝氨酸 酪氨酸 半胱氨酸 C 亮氨酸 丝氨酸 终止码 终止码 A 亮氨酸 丝氨酸 终止码 色氨酸 G C 亮氨酸 脯氨酸
【求助】P53的翻译后修饰都有哪些？ 怎样验证其修饰后与靶标启动子的结合活性的变化？
、Ser376）则和p53降解的增加有关。 顺反异构化修饰 p53的活化涉及构象的改变，由肽脯氨酰-顺反异构酶︱(PIN1）引起的特定的脯氨酸残基的顺反异构化可导致构象的改变。PIN1的蛋白结合位点包括一个磷酸化的丝氨酸或苏氨酸及其后紧跟的一个脯氨酸，从而催化脯氨酸残基发生顺反异构化。目前对Ser127-Pro128、Thr150-Pro151基序是否受PIN1的靶向作用还不清楚。PIN1引起的p53构象的改变阻止了MDM2的结合和/或促进了MDM2的解离，从而使
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