- ¥780 - 2200
- LMAI Bio
- LM-1849R
- 进口/国产
- 2025年07月11日
- WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow, Horse, Fruit Fly,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-1849R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Midkine
- 抗体名：
中期因子/肝素结合生长因子抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow, Horse, Fruit Fly,
- 免疫原：
KLH conjugated synthetic peptide derived from human Midkine:23-100/140
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
Midkine中期因子/肝素结合生长因子抗体
| 英文名称 | Midkine |
| 中文名称 | 中期因子/肝素结合生长因子抗体 |
| 别 名 | Amphiregulin associated protein; ARAP; FLJ27379; MDK; Midgestation and kidney protein; MK 1; MK; MK1; NEGF 2; NEGF2; neurite growth promoting factor 2; Neurite outgrowth promoting protein; MK_HUMAN. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 免疫学 生长因子和激素 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, Horse, Fruit Fly, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 13.4kDa |
| 细胞定位 | 分泌型蛋白 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Midkine:23-100/140 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Midkine exhibits neurite outgrowth-promoting activity and may play a role in nervous system development and/or maintenance. Its expression is predominant only for a short period from approximately one-half to two-thirds of the way through gestation; before and after that, it is barely detectable. Midkine was first found in differentiating mouse teratocarcinoma cells. It has neurotrophic activities and is mitogenic to certain, but not to all, fibroblast cell lines. Function: Developmentally regulated, secreted growth factor homologous to pleiotrophin (PTN), which has heparin binding activity. Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation. Involved in neointima formation after arterial injury, possibly by mediating leukocyte recruitment. Also involved in early fetal adrenal gland development (By similarity). Subunit: Homodimer. Interacts with ALK. Subcellular Location: Secreted. Similarity: Belongs to the pleiotrophin family. SWISS: P21741 Gene ID: 4192 Database links: Entrez Gene: 280852 Cow Entrez Gene: 4192 Human Entrez Gene: 17242 Mouse Entrez Gene: 81517 Rat Omim: 162096 Human SwissProt: P21741 Human SwissProt: P12025 Mouse SwissProt: Q9R1S9 Rat Unigene: 21528 Cow Unigene: 82045 Human Unigene: 906 Mouse Unigene: 17447 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 中期因子(midkine, MK)具有多种生物学功能: 可促进神经轴突 的生长和各种胚胎神经元的存活,做为一种有丝分裂原,与肿瘤的发生密切相关，MK还有较强的 促血管生成特性, 经研究证实, MK可促进内皮细胞增殖并 提高血管的密度，在多种肿瘤组织和肿 瘤患者的血清中的水平都明显升高。MK和多向促激素(p leiotro2 phin, PTN)同属于一类新的结合肝素的生长因子家 族。 |
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