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- 2026年04月05日
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合研生物
- 服务名称：
核受体筛选
武汉合研生物医药科技有限公司坐落于光谷生物城，是一家专注于提供新药发现阶段的技术服务，以中小微新药研发企业为服务主体的创新型公司。合研生物拥有一支训练有素的药物研发技术团队，提供的服务覆盖虚拟筛选、酶学靶点筛选、抗肿瘤药物活性评价、细胞功能学检测、药理病理学服务等各项技术。我们的技术团队在分子生物学、细胞生物学、结构生物学等领域具有丰富的经验，通过酶水平、细胞水平测定等技术平台帮助客户进行化合物筛选及化合物特性、作用机制等研究。合研生物以高效、高性价比的专业服务帮助客户更快地达到目标，帮助客户推进药物发现的进程。
我们的优势
合研生物拥有丰富的核受体筛选经验，可提供96孔板型的筛选模式，加速您的药物研发进程。
| Target | Assay | Format |
| ER alpha | Cell based | 96 |
| ER beta | Cell based | 96 |
| glucocorticoid receptor (GR) | Cell based | 96 |
| LXR (liver X receptor) beta | Cell based | 96 |
| Androgen Receptor | Cell based | 96 |
| Constitutive Androstane Receptor (CAR) | Cell based | 96 |
| ERR (estrogen related receptor) alpha | Cell based | 96 |
| ERR (estrogen related receptor) beta | Cell based | 96 |
| Estrogen Related Receptor (ERR) gamma | Cell based | 96 |
| FXR (farnesoid X receptor) | Cell based | 96 |
| LXR (liver X receptor) alpha | Cell based | 96 |
| PPAR alpha | Cell based | 96 |
| PPAR delta | Cell based | 96 |
| PPAR gamma | Cell based | 96 |
| Progesterone Receptor | Cell based | 96 |
| PXR (SXR) | Cell based | 96 |
| RAR (retinoic acid receptor) beta | Cell based | 96 |
| Retinoic Acid Receptor (RAR) alpha | Cell based | 96 |
| Retinoic Acid Receptor (RAR) gamma | Cell based | 96 |
| Retinoid X Receptor (RXR) beta | Cell based | 96 |
| TR (thyroid receptor) alpha | Cell based | 96 |
| TR (thyroid receptor) beta | Cell based | 96 |
| TR-FRET LXR (liver X receptor) beta | Cell based | 96 |
| Vitamin D Receptor (VDR) | Cell based | 96 |
| mineralocorticoid receptor(MR) | Cell based | 96 |
| Retinoid X Receptor (RXR) alpha | Cell based | 96 |
| Retinoid X Receptor (RXR) gamma | Cell based | 96 |
| constitutive androstane receptor isoform 1 | Cell based | 96 |
| constitutive androstane receptor isoform 3 | Cell based | 96 |
| RAR-related orphan receptor gamma (RORγ) | Cell based | 96 |
| Aryl Hydrocarbon Receptor | Cell based | 96 |
| Pregnane X Receptor | Cell based | 96 |
| Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) | Cell based | 96 |
| Liver Receptor Homolog-1 | Cell based | 96 |
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文献和实验Cell-Based Assays for Identification of Aryl Hydrocarbon Receptor (AhR) Activators
The Ah receptor (AhR) is a ligand-dependent transcription factor that mediates a wide range of biological and toxicological effects from exposure to structurally diverse synthetic and naturally occurring chemicals. The role of the AhR
. GRA of the aryl hydrocarbon receptor (AhR) relies on the in vitro ability of the cytosolic AhR protein complex to convert into its high affinity DNA binding form following its interaction with and activation by an AhR agonist and, as such, the GRA
中科院张利民发现「人工代糖」导致脂肪肝！「代糖」还是天然的好
，那就是代糖。 但代糖真的百利而无一害吗？学术界一直没有定论。 图片来源：mSystems 2021 年 3 月，来自中国科学院武汉物理与数学研究所的张利民研究员带领团队，在微生物学领域著名期刊 mSystems 上刊登了题为 Impaired Intestinal Akkermansia muciniphila and Aryl Hydrocarbon Receptor Ligands Contribute to Nonalcoholic Fatty Liver Disease in Mice
