Dermokine beta antibody

Dermokine beta antibody

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  • ¥1380 - 2200
  • 康朗生物
  • kl-9056R
  • 中国/美国/德国
  • 2025年11月07日
  • ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200
  • Rabbit
  • Human, Rat,
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    • 详细信息
    • 技术资料
    • 供应商

      上海康朗生物科技有限公司

    • 库存

      大量

    • 目录编号

      kl-9056R

    • 克隆性

      多克隆

    • 抗原来源

      Rabbit

    • 保质期

      12个月

    • 抗体英文名

      Dermokine beta antibody

    • 抗体名

      Dermokine β蛋白抗体

    • 宿主

      Rabbit

    • 适应物种

      Human, Rat,

    • 免疫原

      KLH conjugated synthetic peptide derived from human Dermokine beta:401-476/476

    • 亚型

      IgG

    • 形态

      冻干粉或液体

    • 应用范围

      ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200

    • 浓度

      1mg/ml

    • 保存条件

      -20 °C

    • 规格

      100ul 200ul

    Dermokine beta antibody
    中文名称 Dermokine β蛋白抗体
    别    名 Dermokineβ; Dermokine-β; DMKN;Dermokine beta; Dermokine delta 1; Dermokine delta 5a; Dermokine delta 5b; Dermokine gamma 1; Dermokine gamma 2; UNQ729; ZD52F10 protein; Epidermis-specific secreted protein SK30/SK89; DMKN_HUMAN.  
    规格价格 100ul/1380元 购买    200ul/2200元 购买    大包装/询价
    说 明 书 100ul  200ul
    研究领域 细胞生物  免疫学  
    抗体来源 Rabbit
    克隆类型 Polyclonal
    交叉反应 Human, Rat, 
    产品应用 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:50-200 (石蜡切片需做抗原修复) 
    not yet tested in other applications.
    optimal dilutions/concentrations should be determined by the end user.
    分 子 量 45kDa
    细胞定位 分泌型蛋白 
    性    状 Lyophilized or Liquid
    浓    度 1mg/ml
    免 疫 原 KLH conjugated synthetic peptide derived from human Dermokine beta:401-476/476 
    亚    型 IgG
    纯化方法 affinity purified by Protein A
    储 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
    保存条件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
    PubMed PubMed
    产品介绍 background:
    Dermokine, also known as DMKN, ZD52F10 or UNQ729, is a 476 amino acid secreted protein that belongs to the dermokine family and exists as 15 alternatively spliced isoforms, the most notable of which are designated å and ∫. Existing as a homooligomer that can either homodimerize or homotrimerize, Dermokine is expressed in the epidermis, as well as in the epithelia of the lung and small intestine where it is thought to function as a regulator of keratinocyte differentiation, possibly playing a role in inflammatory responses. The gene encoding Dermokine maps to human chromosome 19, which consists of over 63 million bases, houses approximately 1,400 genes and is recognized for having the greatest gene density of the human chromosomes. It is the genetic home for a number of immunoglobulin (Ig) superfamily members, including the killer cell and leukocyte Ig-like receptors, a number of ICAMs, the CEACAM and PSG family and Fc receptors (FcRs).

    Function:
    May act as a soluble regulator of keratinocyte differentiation (Potential). 

    Subunit:
    Homooligomer. Seems to be able to homodimerize and homotrimerize. 

    Subcellular Location:
    Secreted. 

    Tissue Specificity:
    Expressed in epidermis; in the spinous and granular layers and in placenta. Also found in the epithelia of the small intestine, macrophages of the lung and endothelial cells of the lung. Isoform 15 is expressed in epidermis and placenta. Isoform 1 is expressed in epidermis. 

    Post-translational modifications:
    O-glycosylated. 

    Similarity:
    Belongs to the dermokine family. 

    SWISS:
    Q6E0U4

    Gene ID:
    93099

    Database links:

    Entrez Gene: 93099 Human

    SwissProt: Q6E0U4 Human

    SwissProt: Q96EW8 Human

    Unigene: 417795 Human



    Important Note:
    This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
     
    产品图片 Dermokine beta antibody
    Tissue/cell: rat small intestine tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; 
    Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; 
    Incubation: Anti-Dermokine beta Polyclonal Antibody, Unconjugated(bs-9056R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining

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