Recombinant Human Visfatin

Recombinant Human Visfatin

产品描述

Visfatin is a 55 kDa protein produced and secreted primarily by white adipose tissue. Recently, visfatin was isolated from visceral fat deposits and shown to possess insulin-mimetic activity. Like insulin, visfatin exerts hypoglycemic effects by interacting with the insulin receptor. The binding affinity of visfatin for the insulin receptor is similar to that of insulin, but it does not compete with insulin, suggesting that the two proteins interact with different receptor sites. The circulating levels of visfatin are much lower than those of insulin and are not affected by feeding, implying that the hypoglycemic effect of visfatin may not be of physiological importance. The plasma visfatin levels, like those of leptin, correlate positively with the percent of body fat, and increase during the development of obesity. Another similarity between visfatin and leptin is that their amino acid sequence is highly conserved across different mammalian species and shows no homology to any known protein.

Source:E.coli

Synonyms:PBEF (Pre-B cell colony-enhancing factor), NAmPRTase (nicotinamide phosphoribosyltransferase), Nampt, VF
 

Purity:≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:The ED₅₀ ​was determined by the dose-dependent proliferation of the RPMI 8226 cells. The expected ED₅₀ ​for this effect is 15.0-20.0 ng/ml.

     上海嵘崴达实业有限公司，专业经营生命科学领域的科研试剂、仪器和实验室消耗品，

致力于向国内生命科学研究人员提供合格产品和完善服务。

主要经营的试剂品牌：
Roche试剂，部分常用现货，周三定货，2-3周到货。
GE试剂，耗材，部分常用现货，周二，周五定货，3周左右。
SIGMA试剂，周一，五定货，3周左右到货。
THERMO试剂，部分现货，周三定货，2-3周到货。
ABCAM试剂，国内现货三天左右，期货四周左右。
Peprotech试剂，部分常用现货，周三定货，2-3周到货。

罗氏原料，请来电来邮咨询。

OXOID，BD培养基货期八周左右，部分现货。
MCE激动剂，ACROS、ALFA、阿拉丁等生化试剂现货定购。