- ¥1380 - 2200
- LMAI Bio
- LM-11220R
- 进口/国产
- 2026年11月02日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
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- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-11220R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
PTBP1
- 抗体名：
核糖核酸结合蛋白1抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from human PTBP1:451-531/531
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | PTBP1 |
| 中文名称 | 核糖核酸结合蛋白1抗体 |
| 别 名 | Heterogeneous nuclear ribonucleoprotein I; Heterogeneous Nuclear Ribonucleoprotein Polypeptide I; hnRNP I; HNRNPI; HNRPI; MGC10830; MGC8461; Polypyrimidine Tract Binding Protein 1; Polypyrimidine tract binding protein; Polypyrimidine tract-binding protein 1; pPTB; PTB 1; PTB 2; PTB 3; PTB 4; PTB; PTB T; PTB1; PTB2; PTB3; PTB4; PTBP 1; PTBP1; PTBP1_HUMAN; PTBT; RNA Binding Protein; 57 kDa RNA binding protein PPTB 1; 57 kDa RNA binding protein PPTB1; 57 kDa RNA-binding protein PPTB-1. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 染色质和核信号 结合蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 57kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human PTBP1:451-531/531 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Function: Plays a role in pre-mRNA splicing and in the regulation of alternative splicing events. Activates exon skipping of its own pre-mRNA during muscle cell differentiation. Binds to the polypyrimidine tract of introns. May promote RNA looping when bound to two separate polypyrimidine tracts in the same pre-mRNA. May promote the binding of U2 snRNP to pre-mRNA. Cooperates with RAVER1 to modulate switching between mutually exclusive exons during maturation of the TPM1 pre-mRNA. Represses the splicing of MAPT/Tau exon 10. Subunit: Contains 4 RRM (RNA recognition motif) domains. Subcellular Location: Nucleus. Similarity: Contains 4 RRM (RNA recognition motif) domains. SWISS: P26599 Gene ID: 5725 Database links: Entrez Gene: 5725 Human Entrez Gene: 19205 Mouse Entrez Gene: 29497 Rat Omim: 600693 Human SwissProt: P26599 Human SwissProt: P17225 Mouse SwissProt: Q00438 Rat Unigene: 172550 Human Unigene: 265610 Mouse Unigene: 472059 Mouse Unigene: 64440 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |
Sample:
Jurkat(Human) Cell Lysate at 30 ug Primary: Anti-PTBP1 (bs-11220R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kD Observed band size: 57 kD 
Sample:
A549(Human) Cell Lysate at 30 ug Primary: Anti-PTBP1 (bs-11220R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 57 kD Observed band size: 57 kD 
Paraformaldehyde-fixed, paraffin embedded (Human colon carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (PTBP1) Polyclonal Antibody, Unconjugated (bs-11220R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.
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文献和实验Sca-1被广泛认为和Ly-6 半抗原一起，是小鼠HSC标志分子，它在多能HSCs上表达。一种抗Sca-1抗体经常和一些细胞表面标志分子表达的阴性选择一起用来鉴定和分离小鼠HSCs. Sca-1+ HSCs可在成年骨髓、胎儿肝脏、成年动物流动的外周血和脾脏中被找到。Sca-1在几种非造血组织中也被发现。43可用来富集HSCs之外的祖细胞。Sca-1 可能参与调节B细胞和T细胞活化。 间质干细胞的标志物 STRO-1: 用CD34阳性骨髓细胞进行免疫产生的小鼠IgM单抗STRO-1, 能识别
有助于我们了解细胞如何保证一种蛋白在折叠时不受其他蛋白聚集体影响的机制。 只有还原脱钙的牛乳清白蛋白能够被蛋白聚集体诱导而发生聚集 牛乳清白蛋白（LA）是一种钙结合蛋白，其不同状态的构象已为很好鉴定，因此是蛋白质折叠研究的好材料。还原脱钙的牛乳清白蛋白（r-LA）在25℃中性还原性的缓冲液中是可溶性蛋白，以“前熔球态”存在。但是随着不同种类蛋白聚集体的加入，r-LA便发生聚集。但蛋白聚集体不能诱导天然的LA和只脱钙的处于“熔球态”的LA发生聚集。分子伴侣蛋白二硫键异构酶或者化学分子伴侣聚乙
-transferase)二、足印法（Footprinting） 足印法（Footprinting）是一种用来测定DNA-蛋白质专一性结合的方法，用于检测目的DNA序列与特定蛋白质的结合，也可展示蛋白质因子同特定DNA片段之间的结合。其原理为：DNA和蛋白质结合后，DNA与蛋白的结合区域不能被DNase（脱氧核糖核酸酶）分解，在对目的DNA序列进行检测时便出现了一段无DNA序列的空白区(即蛋白质结合区)，从而了解与蛋白质结合部位的核苷酸数目及其核苷酸序列。三、染色质免疫共沉淀技术（Chromatin
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