C3a Receptor antibody

价格¥1380 - 2200

品牌康朗生物
货号kl-2955R
产地中国/美国/德国
更新日期2025年07月12日

应用范围WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
宿主Rabbit
适应物种Human, Mouse, Rat, Horse, Rabbit,

上海康朗生物科技有限公司

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详细信息
技术资料

供应商：
上海康朗生物科技有限公司
库存：
大量
目录编号：
kl-
克隆性：
多克隆
抗原来源：
Rabbit
保质期：
12个月
抗体英文名：
C3a Receptor antibody
抗体名：
过敏毒素C3受体/补体C3受体抗体
宿主：
Rabbit
适应物种：
Human, Mouse, Rat, Horse, Rabbit,
免疫原：
KLH conjugated synthetic peptide derived from human C3a Receptor/C3aR:401-482/482 <Cytoplasmic>
亚型：
IgG
形态：
冻干粉或液体
应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
浓度：
1mg/ml
保存条件：
-20 °C
规格：
100ul 200ul

C3a Receptor antibody

中文名称	过敏毒素C3受体/补体C3受体抗体
别名	AZ 3B; AZ3B; C3a anaphylatoxin chemotactic receptor; C3A R; C3A R1; C3a-R; C3AR; C3AR_HUMAN; C3AR1; C3R1; Complement component 3 receptor 1; Complement component 3a receptor 1; HNFAG09.
	Specific References (1) \| bs-2955R has been referenced in 1 publications. [IF=5.29] Shinjyo, Noriko, et al. "Complement Peptide C3a Promotes Astrocyte Survival in Response to Ischemic Stress." Molecular Neurobiology (2015): 1-12. WB ; Mouse. PubMed:25972241
规格价格	100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	100ul 200ul
研究领域	免疫学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Horse, Rabbit,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	54kDa
细胞定位	细胞膜
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human C3a Receptor/C3aR:401-482/482 <Cytoplasmic>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: Complement C3 precursor contains complement C3 beta chain, complement C3 alpha chain, C3a anaphylatoxin, complement C3b alpha chain, complement C3c fragment, complement C3dg fragment, complement C3g fragment, complement C3d fragment and complement C3f fragment. C3a, C4a, and C5a are potent anaphylatoxins that are released during complement activation, a system of ligand-surface protein interactions specific to cells of hematopoietic lineage that aids in the elimination of pathogens. C3a and C5a secretion correlates with pathophysiological phenotypes such as asthma and bacterial meningitis. Binding of these proteins to their respective G protein-coupled receptors (C3aR, C5aR), which are present on the surface of myeloid leukocytes, induces proinflammatory events such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3aR is expressed in brain and activated B-lymphocytes whereas C5aR is prevalent on the surface of hepatocyte, lung, smooth muscle, and endothelial cells. Upon activation, C3aR and C5aR are susceptible to rapid GRK-mediated phosphorylation and clathrin-coated vesicle targeting. C5aR utilizes the Ras-Raf-ERK1/2 cascade and couples to Gi/G16 proteins. Function: Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. Subcellular Location: Cell membrane; Multi-pass membrane protein. Tissue Specificity: Widely expressed in several differentiated hematopoietic cell lines, in the lung, spleen, ovary, placenta, small intestine, throughout the brain, heart, and endothelial cells. Mostly expressed in lymphoid tissues. Post-translational modifications: Among the sulfation sites Tyr-174 is essential for binding of C3a anaphylatoxin. Similarity: Belongs to the G-protein coupled receptor 1 family. SWISS: Q16581 Gene ID: 719 Database links: Entrez Gene: 719 Human Entrez Gene: 12267 Mouse Entrez Gene: 84007 Rat Omim: 605246 Human SwissProt: Q16581 Human SwissProt: O09047 Mouse SwissProt: O55197 Rat Unigene: 591148 Human Unigene: 2408 Mouse Unigene: 9772 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品图片	Sample: K562(Human) Cell Lysate at 30 ug 293T(Human) Cell Lysate at 30 ug A549(Human) Cell Lysate at 30 ug Lung (Mouse) Lysate at 40 ug Primary: Anti-C3a Receptor (bs-2955R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54 kD Observed band size: 64 kD Sample: 293T Cell (Human) Lysate at 30 ug Primary: Anti-C3a Receptor (bs-2955R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54kD Observed band size: 60kD Sample: A549 Cell (Human) Lysate at 30 ug Primary: Anti-C3a Receptor (bs-2955R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 54kD Observed band size: 60kD Paraformaldehyde-fixed, paraffin embedded (human gastric carcinoma); Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with (C3a Receptor) Polyclonal Antibody, Unconjugated (bs-2955R) at 1:400 overnight at 4°C, followed by operating according to SP Kit(Rabbit) (sp-0023) instructionsand DAB staining.