重组人XPNPEP3(国产,进口)

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括重组人XPNPEP3(国产,进口)在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：重组人XPNPEP3(国产,进口)
编号：JN1754
规格：10μg|50μg|500μg|1mg
英文名：Recombinant Human Probable Xaa-Pro Aminopeptidase 3
品牌：百奥莱博
产地：北京
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Ser507在N端、C端都带有His标签。

XPNPEP3质量控制：＞95%(还原性SDS-PAGE)

XPNPEP3制剂：液体

XPNPEP3保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于XPNPEP3：
Probable Xaa-Pro Aminopeptidase 3 (XPNPEP3) is a member of the peptidase M24B family. XPNPEP3 has two isoforms and both are widely expressed. XPNPEP3 is localized in the Mitochondrion. XPNPEP3 catalyzes the release of any N-terminal amino acid, including proline, that is linked to proline, even from a dipeptide or tripeptide. Defects in XPNPEP3 are the cause of nephronophthisis-like nephropathy type 1 which is a disorder with features of nephronophthisis, a cystic kidney disease leading to end-stage renal failure.

重组人XPNPEP3(国产,进口)极具性价比，此外，我公司正火爆促销以下产品：

·重组人热反应蛋白12(HRSP12)
编号：JN2026
英文名称：Recombinant Human Heat-Responsive Protein 12
规格：10μg|50μg|500μg|1mg
本品由我们的大肠杆菌表达系统制备而成，目的基因编码的Met1-Leu137在N端含有His标签。

HRSP12质量控制：＞95%(还原性SDS-PAGE)

HRSP12制剂：液体

HRSP12保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于HRSP12：
Heat-Responsive Protein 12 (HRSP12) is an endoribonuclease that belongs to the Rut family. HRSP12 is found mainly in the human adult kidney and liver and is responsible for inhibiting protein translation by cleaving mRNA. HRSP12 only cleaves phosphodiester bonds in single-stranded RNA and inhibits cell-free protein synthesis. The levels of both mRNA and protein are markedly reduced in heptatocellular tumors and in human hepatoma cell lines comp*(代"a")red with normal liver tissues. Moreover the levels of HRSP12 are different depending on the grade of the tumor. This had led to the suggestion that HRSP12 may be an important biomarker for heptatic carcinoma.


重组人XPNPEP3(国产,进口)关键词：Recombinant Human Probable Xaa-Pro Aminopeptidase ,JN1754,重组XPNPEP3,重组人XPNPEP3蛋白,百奥莱博

SV1126 核酸内切酶 III（Nth） Nucleic acid enzyme III (Nth)
YT097 抗荧光淬灭封片液 Antifade Mounting Medium
BTN120653A 填入法DNA末端标记试剂盒 Fill-in DNA End Labeling Kit
SY0417 70mm透析袋(透析分子量14kDa) Dialysis Tube MD77 (Mw14,000)
SV0266 BstXI限制性内切酶 BstXI Restriction Endonuclease
KFS377 活性氧ROS检测荧光探针-DHE,红300/610
SY0625 6-苄*基嘌呤 6-Benzylamino Purine
SY0056 NTP套装(100 mM each) NTP Set (ATP, CTP, UTP, GTP, 100 mM each)
BTN131087 AP标记亲和素 AP-Avidin
KFS032 即用型免疫组织化学SP试剂盒(Rabbit)
SY0259 双链DNA(dsDNA)定量试剂 Picogreen dsDNA Quantitation Reagent
YT344 NF-κB抑制剂/抗氧化剂(PDTC) Ammonium pyrrolidinedithiocarbamate
重组人XPNPEP3(国产,进口)关键词：Recombinant Human Probable Xaa-Pro Aminopeptidase ,JN1754,重组XPNPEP3,重组人XPNPEP3蛋白,百奥莱博


·重组小鼠PD-1(程序性细胞死亡蛋白1)
编号：JN1894
英文名称：Recombinant Mouse Programmed Cell Death Protein 1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu25-Gln167在C端带有Fc标签。

PD-1质量控制：＞95%(还原性SDS-PAGE)

PD-1制剂：冻干品

PD-1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

PD-1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于PD-1：
Programmed Death-1 (PD-1), firstly cloned from mouse T cell hybridoma 2B4.11, is one member of CD28/CTLA-4 superfamily. PD-1 belongs to type I transmembrane protein and acts as an important immunosuppressive molecule. This family also include members of CD28, CTLA-4 and ICOS.The mouse Programmed Death-1 protein, encoded by PD-1 gene, comprises four parts including a putative 20 aa signal peptide, a 149 aa extracellular region, a 21 aa transmembrane domain and a 98 aa cytoplasmic region. The cytoplamsic tail of PD-1 contains two structural motifs, an immunoreceptor tyrosine-based inhibitory motif (ITIM) and an immunoreceptor tyrosine-based switch motif (ITSM) formed by two tyrosine residues which make the difference in PD-1 signal mediating.Mouse PD-1 is expressed in thymus and shares about 69% aa sequence identity with human PD-1. Recently, programmed death-1 (PD-1) with its ligands, programmed death ligand B7H1 (PD-L1) and B7DC (PD-L2), was found to regulate T-cell activation and tolerance, upon ligand binding, inhibiting T-cell effector functions in an antigen-specific manner.PD-1 gene knocked out mice would induce some autoimmune diseases, which suggests that PD-1 acts as a co-inhibitory molecule actively participating in maintaining peripheral tolerance. Thus, PD-1 may be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation.

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