- ¥780 - 2200
- LMAI Bio
- LM-0738R
- 进口/国产
- 2025年07月11日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Dog, Cow,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-0738R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
Livin
- 抗体名：
凋亡抑制蛋白抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Dog, Cow,
- 免疫原：
KLH conjugated synthetic peptide derived from human Livin C-terminus:101-200/298
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
50ul 100ul 200ul
Livin凋亡抑制蛋白抗体
| 英文名称 | Livin |
| 中文名称 | 凋亡抑制蛋白抗体 |
| 别 名 | Baculoviral IAP repeat containing 7; Baculoviral IAP repeat containing protein 7; BIRC 7; BIRC7; BIRC7_HUMAN; KIAP; Kidney inhibitor of apoptosis protein; LIVIN; Livin inhibitor of apotosis; Melanoma inhibitor of apoptosis protein; ML IAP; MLIAP; RING finger protein 50; RNF 50; RNF50; Inhibitors of apoptosis proterins Livin. |
| 规格价格 | 50ul/780元 购买 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 50ul 100ul 200ul |
| 研究领域 | 肿瘤 细胞生物 信号转导 细胞凋亡 细胞周期蛋白 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Dog, Cow, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 33kDa |
| 细胞定位 | 细胞核 细胞浆 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human Livin C-terminus:101-200/298 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Livin is a novel member of the IAP protein family and contains a single baculoviral IAP repeat (BIR) domain and a RING finger domain and has two isoforms termed Livin alpha and Livin beta. The BIR domain is essential for inhibitory activity and interacts with caspases, while the RING finger domain sometimes enhances antiapoptotic activity but does not inhibit apoptosis alone. The two isoforms of Livin appear to have different functions and tissue distributions. Function: Protects against apoptosis induced by TNF or by chemical agents such as adriamycin, etoposide or staurosporine. Suppression of apoptosis is mediated by activation of MAPK8/JNK1, and possibly also of MAPK9/JNK2. This activation depends on TAB1 and NR2C2/TAK1. In vitro, inhibits caspase-3 and proteolytic activation of pro-caspase-9. Isoform 1 blocks staurosporine-induced apoptosis. Isoform 2 blocks etoposide-induced apoptosis. Subcellular Location: Nucleus. Cytoplasm. Nuclear, and in a filamentous pattern throughout the cytoplasm. Tissue Specificity: Isoform 1 and isoform 2 are expressed at very low levels or not detectable in most adult tissues. Detected in adult heart, placenta, lung, lymph node, spleen and ovary, and in several carcinoma cell lines. Isoform 2 is detected in fetal kidney, heart and spleen, and at lower levels in adult brain, skeletal muscle and peripheral blood leukocytes. Similarity: Belongs to the IAP family. Contains 1 BIR repeat. Contains 1 RING-type zinc finger. SWISS: Q96CA5 Gene ID: 79444 Database links: Entrez Gene: 79444 Human Omim: 605737 Human SwissProt: Q96CA5 Human Unigene: 256126 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Livin—属于凋亡蛋白抑制因子家族（inhibitor of apoptosis proteins，IAP） Livin是凋亡抑制蛋白家族的新成员，主要通过抑制Caspases蛋白发挥抑制细胞凋亡的作用,主要在胎盘组织中表达，同时在一些肿瘤组织中呈高表达，尤其是在黑色素瘤细胞系表达水平最高。 经研究表明，Livin与肿瘤的发生、发展关系密切,是一个有潜在价值的肿瘤标志物，此外，反义Livin以及Livin活性抑制物的研究有望成为肿瘤治疗的新靶点。 |
| 产品图片 |  Sample:Lymph node (Mouse) Lysate at 40 ug Primary: Anti-Livin (bs-0738R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 33 kD Observed band size: 35 kD  Tissue/cell: Human endometrium carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-Livin Polyclonal Antibody, Unconjugated(bs-0738R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining |
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文献和实验相关实验
人凋亡抑制蛋白（livin ） 酶联免疫分析（ ELISA ） 试剂盒使用说明书 本试剂仅供研究使用 目的：本试剂盒用于测定人血清，血浆及相关液体样本中凋亡抑制蛋白（livin ）的 含量。 实验原理： 本试剂盒应用双抗体夹心法测定标本中 人凋亡抑制蛋白（ livin ） 水平。用纯化的 人凋亡抑制蛋白（ livin ）抗体 包被微孔板，制成固相抗体，往包被单抗的微孔中依次加入 凋亡抑制蛋白（ livin
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Livin凋亡抑制蛋白抗体
¥780 - 2200
