- ¥1380 - 2200
- LMAI Bio
- LM-6921R
- 进口/国产
- 2025年12月23日
- WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- Rabbit
- Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
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- 详细信息
- 文献和实验
- 技术资料
- 供应商：
上海联迈生物工程有限公司
- 库存：
大量
- 目录编号：
LM-6921R
- 克隆性：
多克隆
- 抗原来源：
Rabbit
- 保质期：
1年
- 抗体英文名：
CCDC98
- 抗体名：
卷曲螺旋结构域蛋白98抗体
- 宿主：
Rabbit
- 适应物种：
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep,
- 免疫原：
KLH conjugated synthetic peptide derived from humna CCDC98:51-150/409
- 亚型：
IgG
- 形态：
Lyophilized or Liquid
- 应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复）
- 浓度：
1mg/ml
- 保存条件：
Store at -20 °C
- 规格：
100ul 200ul
| 英文名称 | CCDC98 |
| 中文名称 | 卷曲螺旋结构域蛋白98抗体 |
| 别 名 | BRCA1-A complex subunit Abraxas; CCDC98; coiled coil domain containing 98; Coiled-coil domain-containing protein 98; F175A_HUMAN; FAM175A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A. |
| 规格价格 | 100ul/1380元 购买 200ul/2200元 购买 大包装/询价 |
| 说 明 书 | 100ul 200ul |
| 研究领域 | 细胞生物 免疫学 表观遗传学 |
| 抗体来源 | Rabbit |
| 克隆类型 | Polyclonal |
| 交叉反应 | Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, |
| 产品应用 | WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 47kDa |
| 细胞定位 | 细胞核 |
| 性 状 | Lyophilized or Liquid |
| 浓 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from humna CCDC98:51-150/409 |
| 亚 型 | IgG |
| 纯化方法 | affinity purified by Protein A |
| 储 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存条件 | Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. |
| PubMed | PubMed |
| 产品介绍 | background: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Function: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1. Subunit: Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin. Subcellular Location: Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs). Post-translational modifications: Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Phosphorylated upon DNA damage, probably by ATM or ATR. Similarity: Belongs to the FAM175 family. Abraxas subfamily. SWISS: Q6UWZ7 Gene ID: 84142 Database links: Entrez Gene: 84142 Human Omim: 611143 Human SwissProt: Q6UWZ7 Human Unigene: 334772 Human Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 产品图片 |  Sample: Heart (Mouse) Lysate at 40 ug Primary: Anti-CCDC98 (bs-6921R) at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 47 kD Observed band size: 50 kD |
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文献和实验的编码序列，98 到865 编码VI 型胶原蛋白的α1 链的氨基端球状结构域， 866 到1873 编码胶原的三股螺旋结构域，1874 到3181 编码VI 型胶原蛋白的α1 链的羧基端球状结构域。 接着采用Primer Premier 5.0 进行引物设计，设计结果如下： 图2-1 Primer Premier 5.0 进行引物设计 由表中
酶切位点，应根据下一步实验中要插入PCR 产物的载体的相应序列。 1.1.1 PCR 的引物设计 首先从GenBank 查到VI 型胶原蛋白的α1 链的mRMA 序列，序列号为 NM_001848 .其序列长为 4164bp，其中98 到3184 为VI 型胶原蛋白的α1链的编码序列，98 到865 编码VI 型胶原蛋白的α1 链的氨基端球状结构域， 866 到1873 编码胶原的三股螺旋结构域，1874 到3181 编码VI 型胶原蛋白的α1 链的羧基端球状结构域。
单链抗体可变区基因片段五聚体作用于凋亡诱导配体受体-2来增强其对癌症的治疗作用
单链抗体可变区基因片段(scFvs) 已被看做是一类有前景的药物。然而，它们的低亲和力和快速的血浆清除率限制了其广泛的临床应用。在本研究中，我们旨在通过多聚scFv提高scFv的抗体表达，再通过与人软骨寡聚基质蛋白（COMP）48的螺旋结构域结合以抵抗死亡受体5（DR5，肿瘤坏死因子10B）。通过合成一种五聚体，我们称其为共同体，在体外和体内实验中，scFv的活性增加了10倍，并且共同体比它的单体配对物在抗肿瘤活性方面更有效。标准的抗体类药物正被成功地用于临床治疗癌症。然而，由于标准抗体的低产
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