LDL receptor低密度脂蛋白受体抗体

价格¥780 - 2200

品牌LMAI Bio
货号LM-0705R
产地进口/国产
更新日期2025年07月15日

应用范围WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
宿主Rabbit
适应物种Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,

上海联迈生物工程有限公司

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供应商：
上海联迈生物工程有限公司
库存：
大量
目录编号：
LM-0705R
克隆性：
多克隆
抗原来源：
Rabbit
保质期：
1年
抗体英文名：
LDL receptor
抗体名：
低密度脂蛋白受体抗体
宿主：
Rabbit
适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
免疫原：
KLH conjugated synthetic peptide derived from human LDL-R:781-860/860 <Cytoplasmic>
亚型：
IgG
形态：
Lyophilized or Liquid
应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复）
浓度：
1mg/ml
保存条件：
Store at -20 °C
规格：
50ul 100ul 200ul

LDL receptor低密度脂蛋白受体抗体

英文名称	LDL receptor
中文名称	低密度脂蛋白受体抗体
别名	Low-density lipoprotein receptor precursor; LDL-R; LDL R; FH; FHC; LDL R; LDLR; Low Density Lipoprotein Receptor; Low density lipoprotein receptor familial hypercholesterolemia.
	Specific References (3) \| bs-0705R has been referenced in 3 publications. [IF=2.97] Wu, Hao, et al. "The antihypercholesterolemic effect of jatrorrhizine isolated from Rhizoma Coptidis." Phytomedicine (2014). WB ; PubMed:24894270 [IF=2.70] Kou, Shuming, et al. "Synergetic cholesterol-lowering effects of main alkaloids from Rhizoma Coptidis in HepG2 cells and hypercholesterolemia hamsters." Life Sciences (2016). WB ; Human. PubMed:26876917 [IF=1.55] Jia, Lianqun., et al. "Effects of Tanshinone IIA on the modulation of miR‑33a and the SREBP‑2/Pcsk9 signaling pathway in hyperlipidemic rats." Molecular Medicine Reports (2016). IHC-P ; Rat. PubMed:27082100
规格价格	50ul/780元购买 100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	50ul 100ul 200ul
研究领域	肿瘤免疫学
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Horse, Rabbit, Guinea Pig,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 Flow-Cyt=1μg/Test ICC=1:100-500 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	92kDa
细胞定位	细胞浆细胞膜
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human LDL-R:781-860/860 <Cytoplasmic>
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Function: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Subunit: Interacts with LDLRAP1. Interacts with SNX17. Interacts with HCV E1/E2 heterodimer. Interacts with HIV-1 Tat. Subcellular Location: Cell membrane; Single-pass type I membrane protein. Endomembrane system; Single-pass type I membrane protein. Membrane, clathrin-coated pit; Single-pass type I membrane protein. Note=Found distributed from the plasma membrane to intracellular compartments. Tissue Specificity: Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. In case of HIV-1 infection, functions as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. Post-translational modifications: N- and O-glycosylated. Ubiquitinated by MYLIP leading to degradation. Similarity: Belongs to the LDLR family. Contains 3 EGF-like domains. Contains 7 LDL-receptor class A domains. Contains 6 LDL-receptor class B repeats. SWISS: P01130 Gene ID: 3949 Database links: Entrez Gene: 3949 Human Entrez Gene: 16835 Mouse Entrez Gene: 300438 Rat Omim: 606945 Human SwissProt: P01130 Human SwissProt: P35951 Mouse SwissProt: P35952 Rat Unigene: 213289 Human Unigene: 728190 Human Unigene: 3213 Mouse Unigene: 10483 Rat Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 低密度脂蛋白受体 LDLR是一种存在于细胞表面的、可识别多种配体的脂蛋白受体，在体内对于富含甘油三酯的脂蛋白代谢非常重要; LDL R目前主要用于代谢及肿瘤方面的研究。
产品图片	Sample: K562(Human) Cell Lysate at 30 ug Raw264.7(Mouse) Cell Lysate at 30 ug HepG2(Human) Cell Lysate at 30 ug SW480(Human) Cell Lysate at 30 ug Primary: Anti-LDL receptor (bs-0705R) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 92 kD Observed band size: 120 kD Sample:Human colon Lysate at 45ug; Primary: Anti-LDL receptor (bs-0705R) at 1:300 dilution; Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000 dilution; Predicted band size : 92kD Observed band size : 92kD Sample: K562 Cell (Human) Lysate at 30 ug Primary: Anti- LDL receptor (bs-0705R)at 1/300 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 92kD Observed band size: 117kD Blank control：A431. Primary Antibody (green line): Rabbit Anti-LDL receptor antibody (bs-0705R),Dilution: 1μg /10^6 cells. Isotype Control Antibody (orange line): Rabbit IgG. Secondary Antibody:Goat anti-rabbit IgG-AF647,Dilution: 1μg /test. Protocol A431 cells were fixed with 4% PFA (10min at room temperature)and then permeabilized with 20% PBST for 20 min at room temperature. The cells were then incubated in 5%BSA to block non-specific protein-protein interactions for 30 min at room temperature .Cells stained with Primary Antibody for 30 min at room temperature. The secondary antibody used for 40 min at room temperature. Acquisition of 20,000 events was performed. Blank control (black line): HepG2 (black) (The cells were fixed with 2% paraformaldehyde (10 min) , then permeabilized with PBST for 30 min on room temperature) Primary Antibody (green line): Rabbit Anti-LDLreceptor antibody (bs-0705R) ; Dilution: 1μg /10^6 cells; Isotype Control Antibody (orange line): Rabbit IgG . Secondary Antibody (white blue line): Goat anti-rabbit IgG-FITC;Dilution: 1μg /test.