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- 详细信息
- 文献和实验
- 技术资料
- 库存：
现货
- 英文名：
-)-Norepinephrine
- CAS号：
51-41-2
- 供应商：
鹿森生物
- 保存条件：
低温
一般描述
Norepinephrine is a neurotransmitter found in both the peripheral and central nervous systems. It triggers effects associated with the ′fight or flight′ response and is mediated by the family of adrenergic receptors. Structurally, it is a catecholamine due to the presence of the catechol moiety (consisting of two hydroxyl groups on a benzene ring) and an amine (NH2) group.[1] Norepinephrine exhibits pharmacologic effects on α1 and β1 adrenoceptors. It does not elevate heart rate. The primary advantage of norepinephrine is to improve organ perfusion by increasing vascular tone. Compared to dopamine, norepinephrine is more effective at achieving targeted endpoints, less metabolically active than epinephrine, and reduces serum lactate levels. Moreover, it notably enhances renal perfusion and splanchnic blood flow in sepsis, especially when used alongside d obutamine.[2] Norepinephrine is used in the treatment of hypotension, depression, schizophrenia, and attention deficit/hyperactivity disorders.
应用
(−)-Norepinephrine has been used:
as anαand β-AR agonist to stimulate mouse organoids to study the pathways that are activated upon intestinal epithelial adrenergic receptor (AR) stimulation[3],
to measure the monoamine levels in various limbic regions of mouse brains by high-performance liquid chromatography (HPLC) coupled with an electrochemical equipped with an auto-sampler[4],
as a dispersal agent in biofilm dispersion assay to study its effects on the dispersal of Mannheimia haemolytica biofilms[5]
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文献和实验左旋茶氨酸 L-theanine 即谷酰基乙胺。是从茶叶中发现的（ Y． Saka-to， 1950）。与谷氨酸同样机制合成。
L-DOPA (L-3,4-Dihydroxyphenylalanine)
The nonprotein amino acid, 3,4-dihydroxyphenylalanine (L -DOPA) (Fig. 1) is present in high concentrations (about 3–6%) in Mucuna spp. The in vitro addition of L -DOPA to the red blood cells from individuals deficient in glucose 6-phosphate
L-Mimosine (-(3-Hydroxy-4-Pyridone-1-yl)-L-Alanine)
L -mimosine is a nonprotein amino acid. Despite the consideration of Leucaena leucocephala as a promising alternate source of protein for fodder, the presence of mimosine to the extent of 2% to 10% dry matter in the leaf and 2% to 5% dry
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