ITD-1 is an inducer of TGFβ type II receptor degradation-1, is a potent and highly selective TGFβ pathway inhibitor (IC50=0.85μM).
信号通路
TGF-beta/Smad
靶点
TGFβ
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IC50
0.85μM
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体外研究
ITD-1 selectively enhances the differentiation of uncommitted mesoderm to cardiomyocytes, but not to vascular smooth muscle and endothelial cells. ITD-1 is the first selective TGFβ inhibitor and reveals an unexpected role for TGFβ signaling in controlling cardiomyocyte differentiation from multipotent cardiovascular precursors. ITD-1 downregulates HA-TGFBR2 and TGFBR2-mCherry with nearly the same potency (IC50=1.05 and 1.31μM, respectively). ITD-1 acts by enhancing degradation rather than by blocking synthesis, which would affect cell surface and intracellular receptor pools equally.
体内研究
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临床实验
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特征
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相关实验数据(此数据来自于公开文献,联迈生物并不保证其有效性):
酶活性检测实验
方法
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细胞实验
细胞系
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浓度
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处理时间
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方法
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动物实验
动物模型
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配制
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剂量
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给药方式
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参考文献: 1. Willems E, et al. Cell Stem Cell. 2012 Aug 3, 11(2), 242-252. 包装清单: