罗氏原料10413151103

Glupa-carboxylate
monoammonium salt 10 413 151 103
Substrate for γ-glutamyltransferase
Application
Use Glupa-carboxylate in diagnostic tests for the determination of
γ-glutamyltransferase, according to the recommendations of the International
Federation of Clinical Chemistry and Laboratory Medicine (IFCC).
Benefits
Rely on the proven diagnostic quality of this product.
CAS: 63699-78-5
Properties
Formula: C 12 H 12 N 3 O 7 NH 4
Molecular weight: 328.3 D
Specification
Appearance: White to yellowish crystalline powder
Solubility: Clear, yellow solution in water (c=100 mg/ml), tested for insolubles
pH value: 4.0-6.0
Molar rotation: [α] 25/D +32.0±2.0°
Melting range (Kofler): Approximately +170 to +180°C
Glupa-carboxylate, free acid (enzymatically): ≥87%
Glupa-carboxylate (HPLC): ≥99 area%
Water (K. Fischer): ≤6.2%
NH 4 (Neßler's reagent): 5.2±1%
5-Amino-2-nitrobenzoate (HPLC): ≤0.1 area%
α-Glupa-carboxylate (HPLC): ≤0.4 area%
Thin layer chromatography (silica gel F; n-butanol/glacial acetic acid/H 2 O =
50/15/25; UV, with Nihydrin): Chromatographically homogeneous
A 405 (Glupa-carboxylate, 6 mmol/l): 0.65-0.80
Stability: At +2 to +8°C within specification range for 24 months. Protect from
light.
Additional formulations (tablets) are available on request.
Literature
Schumann G, Bonora R, Ceriotti F, Férard G, Ferrero CA, et al. IFCC primary
reference procedures for the measurement of catalytic activity concentrations
of enzymes at 37 degrees C. International Federation of Clinical Chemistry and
Laboratory Medicine. Part 6. Reference procedure for the measurement of
catalytic concentration of gamma-glutamyltransferase. Clin Chem Lab Med.
2002 Jul, 40 (7): 734-8.