JN1422型重组小鼠Havcr2(Tim-3)优惠促销

特别声明：本产品及我公司所售其他产品均为科研类试剂产品，严禁用于药物、医疗及其他非科研用途。

北京百奥莱博专注于生命科学和生物技术领域，致力于为客户提供包括JN1422型重组小鼠Havcr2(Tim-3)优惠促销在内的一系列分子生物学试剂产品，并提供一系列相关的技术服务。

名称：JN1422型重组小鼠Havcr2(Tim-3)优惠促销
品牌：百奥莱博
产地：国产|进口
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Leu22-Ala193在C端含有His标签。

Havcr2/Tim-3质量控制：＞95%(还原性SDS-PAGE)

Havcr2/Tim-3制剂：冻干品

Havcr2/Tim-3保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

Havcr2/Tim-3复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于Havcr2/Tim-3：
T cell immunoglobulin and mucin domain-3 (TIM3), also called hepatitis A virus cellular receptor 2 (HAVCR2), is a transmembrane glycoprotein of the TIM family of immune regulating molecules and plays an important role in the Th1-mediated immune response. TIM3 is expressed on the Th1 cells, CD8 T-cells, monocytes, and dendritic cells, but not on Th2 cells. TIM3 expressed by monocytes and dendritic cells facilitates phagocytosis of apoptotic cells and up-regulates cross-presentation of apoptotic cell-associated antigens through interaction with phosphatidylserine. Engagement of TIM3 by its ligand galectin-9 induces a range of immunosuppressive functions which enhance immune tolerance and inhibit anti-tumor immunity. Stimulation of TIM3 with an agonistic antibody promotes inflammation through the activation of innate immune cells. TIM3 is also regarded as a potential target molecule for immunotherapy. TIM3 and programmed cell death 1 (PD-1) as two important coinhibitory regulators of T cell responses, have been implicated with the T-cell dysfunction or exhaustion associated with chronic HBV infection including HBV-related HCC.

关于JN1422型重组小鼠Havcr2(Tim-3)优惠促销的更详细说明，请致电我公司咨询，我们将以最饱满的热情为您提供解答，此外，我公司专业供应下列产品：

·重组人MRPL12
编号：JN0794
英文名称：Recombinant Human 39S Ribosomal Protein L12 Mitochondrial/MRPL12
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备而成(人类细胞)，目的蛋白包含序列(Glu46-Glu198) 在C端含有His标签。

MRPL12质量控制：＞95%(SEC-HPLC，还原性SDS-PAGE)

·重组人LAIR1(白细胞相关免疫球蛋白样受体1)
编号：JN1678
英文名称：Recombinant Human Leukocyte-Associated Immunoglobulin-Like Receptor 1
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gln22-His163在C端含有His标签。

LAIR1质量控制：＞95%(还原性SDS-PAGE)

LAIR1制剂：冻干品

LAIR1保存：
冻干蛋白置于-20℃以下可长期保存，室温条件下可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天，可分装后置于-20℃保存三个月。

LAIR1复溶：
打开试剂管前请先离心。
复溶浓度推荐大于100 μg/ml。
冻干蛋白请溶于ddH2O。
复溶后，请根据用量分装冻存，避免反复冻融。

关于LAIR1：
Leukocyte-Associated Immunoglobulin-Like Receptor 1 (LAIR1) is a single-pass type I membrane protein. LAIR1 expressed on the majority of peripheral mononuclear cells, including natural killer (NK) cells, T-cells, B-cells, monocytes, and dendritic cells, highly in naive T-cells and B-cells. As an inhibitory receptor, LAIR1 plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. LAIR1 plays inhibitory role independently of SH2-containing phosphatases and modulates cytokine production in CD4+ T-cells. It down-regulates IL2 and IFNG production while inducing secretion of transforming growth factor beta, also down-regulates IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. LAIR1 inhibits the differentiation of peripheral blood precursors towards dendritic cells. It also restrains proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit/RELA and phosphorylation of I-kappa-B alpha/CHUK in these cells.


JN1422型重组小鼠Havcr2(Tim-3)优惠促销关键词：JN1422,重组小鼠Havcr2,重组小鼠Havcr2蛋白,重组Havcr2,重组小鼠Tim-3


·重组人SPINK4(丝*酸蛋白酶抑制剂Kazal 4型)
编号：JN1718
英文名称：Recombinant Human Serine Protease Inhibitor Kazal-Type 4
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物细胞表达系统制备而成，目的基因编码的Gly27-Cys86在C端含有His标签。

SPINK4质量控制：＞95%(还原性SDS-PAGE)

SPINK4制剂：液体

SPINK4保存：收到货后请置于-20℃，可保存6个月，避免反复冻融。

关于SPINK4：
Serine Protease Inhibitor Kazal-Type 4 (SPINK4) is a secreted protein containing one Kazal-like domain. SPINK4 is a member of the SPINK protein family. The gene family of serine protease inhibitors of the Kazal type (SPINK) are functional and positional candidate genes for celiac disease (CD). SPINK1 plays an important role in protecting the pancreas against excessive trypsinogen activation. It is a potent natural inhibitor of pancreatic trypsin activity. SPINK1 mutations are associated with the development of acute and chronic pancreatitis and have been detected in all forms of chronic pancreatitis. SPINK2 functions as a trypsin/acrosin inhibitor and is synthesized mainly in the testis and seminal vesicle where its activity is engaged in fertility. The SPINK2 protein contains a typical Kazal domain composed by six cysteine residues forming three disulfide bridges. SPINK9 was identified in human skin. Its expression was strong in palmar epidermis, but not detectable or very low in non palmoplantar skin.


JN1422型重组小鼠Havcr2(Tim-3)优惠促销关键词：JN1422,重组小鼠Havcr2,重组小鼠Havcr2蛋白,重组Havcr2,重组小鼠Tim-3


·重组人趋化因子CXCL8(IL-8)
编号：JN0323
英文名称：Recombinant Human C-X-C motif chemokine 8/Interleukin 8
规格：10μg|50μg|500μg|1mg
本品由我们的哺乳动物表达系统制备，目的基因编码的Glu21-Ser99在C端含有His标签。

CXCL8/IL-8质量控制：＞95%(还原性SDS-PAGE)。

CXCL8/IL-8制剂：冻干品

CXCL8/IL-8保存：
冻干蛋白可在-20℃长期保存，室温也可稳定保存3周。
复溶蛋白溶液可在4～7℃保存2～7天。
复溶后建议分装冻存在-20℃，可保存3个月，应避免反复冻融。

CXCL8/IL-8复溶：
1、试剂开盖前请先离心。
2、复溶浓度应大于100 μg/ml.
3、冻干蛋白溶于ddH2O中
4、复溶后根据使用量分装保存，避免反复冻融。

关于CXCL8/IL-8：
Interleukin-8 (IL-8) belongs to the neutrophil-specific CXC family of chemokines. It is one of the initial cytokines released from a variety of cell types, including T cells, endothelial cells and fibroblasts, in response to an inflammatory stimulus and acts by recruiting neutrophils, T-cells and basophils to the site of inflammation. Elevated Interleukin-8 levels are associated with the onset of a variety of disease states.

北京百莱博科技有限公司专业生产供应销*(代"售")生物试剂、化学试剂、抗原抗体、血清血浆、Elisa试剂盒，更多试剂产品需求，欢迎来电咨询选购JN1422型重组小鼠Havcr2(Tim-3)优惠促销。