TIMP-1 antibody

价格¥780 - 2200

品牌康朗生物
货号kl-0415R
产地中国/美国/德国
更新日期2025年07月15日

应用范围WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
宿主Rabbit
适应物种Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,

上海康朗生物科技有限公司

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详细信息
技术资料

供应商：
上海康朗生物科技有限公司
库存：
大量
目录编号：
kl-0415R
克隆性：
多克隆
抗原来源：
Rabbit
保质期：
12个月
抗体英文名：
TIMP-1 antibody
抗体名：
金属蛋白酶组织抑制因子-1抗体
宿主：
Rabbit
适应物种：
Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
免疫原：
KLH conjugated synthetic peptide derived from human TIMP-1:103-207/207
亚型：
IgG
形态：
冻干粉或液体
应用范围：
WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500
浓度：
1mg/ml
保存条件：
-20 °C
规格：
50ul 100ul 200ul

TIMP-1 antibody

中文名称	金属蛋白酶组织抑制因子-1抗体
别名	Clgi; Collagenase inhibitor; EPA; EPO; Erythroid Potentiating Activity; Fibroblast collagenase inhibitor; FLJ90373; HC; Human Collagenase Inhibitor; Metalloproteinase inhibitor 1; Metalloproteinase inhibitor 1 precursor; OTTHUMP00000023214; TIMP 1; TIMP; TIMP metallopeptidase inhibitor 1; TIMP1 protein; Tissue Inhibitor of Metalloproteinase 1; Tissue inhibitor of metalloproteinases; Ttissue inhibitor of metalloproteinase 1 erythroid potentiating activity collagenase inhibitor.
	Specific References (8) \| bs-0415R has been referenced in 8 publications. [IF=3.56] Sassoli, Chiara, et al. "Defining the role of mesenchymal stromal cells on the regulation of matrix metalloproteinases in skeletal muscle cells." Experimental Cell Research (2014). Mouse. PubMed:24631289 [IF=3.53] Lu HY, Huang CY, Shih CM, Chang WH, Tsai CS, et al. (2015) Dipeptidyl Peptidase-4 Inhibitor Decreases Abdominal Aortic Aneurysm Formation through GLP-1-Dependent Monocytic Activity in Mice. PLoS ONE 10(4): e0121077. IHC-P ; Mouse. PubMed:25876091 [IF=2.53] Ni, Wei-Jian, et al. "Renoprotective effects of berberine through regulation of the MMPs/TIMPs system in streptozocin-induced diabetic nephropathy in rats."European Journal of Pharmacology (2015). WB ; Rat. PubMed:26192633 [IF=3.31] Watts, Ryan P., et al. "Novel 24-h ovine model of brain death to study the profile of the endothelin axis during cardiopulmonary injury." Intensive Care Medicine Experimental 3.1 (2015): 31. IHC-P ; PubMed:26596583 [IF=2.62] Sassoli, Chiara, et al. "Low intensity 635 nm diode laser irradiation inhibits fibroblast–myofibroblast transition reducing TRPC1 channel expression/activity: New perspectives for tissue fibrosis treatment." Lasers in Surgery and Medicine (2016). Mouse. PubMed:26660509 [IF=2.14] Lu, Minling, et al. "The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage." Cells Tissues Organs 196.3 (2012): 241-250. IHC-P ; Rabbit. PubMed:22538829 [IF=3.14] Varghese, Sheeja, et al. "The inhibitory effect of anti-tumor polysaccharide from Punica granatum on metastasis." International Journal of Biological Macromolecules (2017). WB ; Human. PubMed:28552725 [IF=1.26] Jiang, Li, Tongfu Zhou, and Hanming Liu. "Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension." Die Pharmazie-An International Journal of Pharmaceutical Sciences 67.6 (2012): 547-552. IHC-P ; Rat. PubMed:22822545
规格价格	50ul/780元购买 100ul/1380元购买 200ul/2200元购买大包装/询价
说明书	50ul 100ul 200ul
研究领域	肿瘤细胞生物神经生物学细胞凋亡生长因子和激素激酶和磷酸酶合成与降解
抗体来源	Rabbit
克隆类型	Polyclonal
交叉反应	Human, Mouse, Rat, Dog, Pig, Cow, Rabbit, Sheep,
产品应用	WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 IF=1:100-500 （石蜡切片需做抗原修复） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user.
分子量	21kDa
细胞定位	分泌型蛋白
性状	Lyophilized or Liquid
浓度	1mg/ml
免疫原	KLH conjugated synthetic peptide derived from human TIMP-1:103-207/207
亚型	IgG
纯化方法	affinity purified by Protein A
储存液	0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件	Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed	PubMed
产品介绍	background: This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction. [provided by RefSeq]. Function: Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Also mediates erythropoiesis in vitro; but, unlike IL-3, it is species-specific, stimulating the growth and differentiation of only human and murine erythroid progenitors. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-11, MMP-12, MMP-13 and MMP-16. Does not act on MMP-14. Subcellular Location: Secreted. Post-translational modifications: The activity of TIMP1 is dependent on the presence of disulfide bonds. Similarity: Belongs to the protease inhibitor I35 (TIMP) family. Contains 1 NTR domain. SWISS: P01033 Gene ID: 7076 Database links: Entrez Gene: 7076 Human Entrez Gene: 21857 Mouse Omim: 305370 Human SwissProt: P01033 Human SwissProt: P12032 Mouse Unigene: 522632 Human Unigene: 8245 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 合成与降解（Synthesis and Degradation） TIMP1是基质金属蛋白酶的抑制酶，其功能与MMP相反，能抑制肿瘤细胞的浸润和转移，主要用于各种恶性肿瘤如乳腺癌等的研究。TIMP-1是一种28kDa的糖蛋白，主要分泌细胞为多种结缔组织细胞，被认为是组织中MMPs活性的主要调节者，它可以和MMPs家族成员以共价键方式形成1:1的复合物，从而发挥其抑制作用。在正常生理条件下，MMPs和TIMPs之间的平衡状态是维持细胞外基质正常状态所必需的，一旦它们之间的比例失调，就会造成一系列的病理状态。
产品图片	Sample: Lane1: Brain(Mouse) Lysate at 30 ug Lane2: Liver (Mouse) Lysate at 30 ug Primary: Anti-TIMP-1 (bs-0415R) at 1:200 dilution; Secondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 3000 dilution; Predicted band size : 21kD Observed band size : 26kD Tissue/cell: human gastric carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-1 Polyclonal Antibody, Unconjugated(bs-0415R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-1 Polyclonal Antibody, Unconjugated(bs-0415R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: human colon carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-1 Polyclonal Antibody, Unconjugated(bs-0415R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining Tissue/cell: rabbit liver tissue; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer ( 0.01M, pH 6.0 ), Boiling bathing for 15min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30min; Blocking buffer (normal goat serum,C-0005) at 37℃ for 20 min; Incubation: Anti-TIMP-1 Polyclonal Antibody, Unconjugated(bs-0415R) 1:200, overnight at 4°C, followed by conjugation to the secondary antibody(SP-0023) and DAB(C-0010) staining