PE标记小鼠抗人CD5单克隆抗体

英文名称human CD5-PE
中文名称PE标记小鼠抗人CD5单克隆抗体
别    名T-cell surface glycoprotein CD5; Lymphocyte antigen 1; Ly-1; Lyt-1; CD5; CD5 antigen; CD 5; CD5 molecule; CD5 antigen (p56 62); CD5_HUMAN; LEU 1; LEU1; Ly12; LyA; Lymphocyte Antigen CD5; Lymphocyte antigen T1/Leu 1; Lymphocyte antigen T1/Leu-1; Lymphocyte glycoprotein T1/Leu1; OTTHUMP00000236973; p56 62; T1.  PE anti-human CD5;
规格50T  
研究领域细胞生物  干细胞  细胞表面分子  
抗体来源Rabbit
克隆类型Polyclonal
交叉反应 Human, 
产品应用Flow-Cyt=20ul/Test （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量55kDa
性    状Liquid
免 疫 原: 
亚    型IgG
纯化方法affinity purified by Protein A
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
This gene encodes a cell surface glycoprotein that regulates complement-mediated cell lysis, and it is involved in lymphocyte signal transduction. This protein is a potent inhibitor of the complement membrane attack complex, whereby it binds complement C8 and/or C9 during the assembly of this complex, thereby inhibiting the incorporation of multiple copies of C9 into the complex, which is necessary for osmolytic pore formation. This protein also plays a role in signal transduction pathways in the activation of T cells. Mutations in this gene cause CD59 deficiency, a disease resulting in hemolytic anemia and thrombosis, and which causes cerebral infarction. Multiple alternatively spliced transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]

Function:
May act as a receptor in regulating T-cell proliferation.

Subunit:
Interacts with CD72/LYB-2. Interacts with PTPN6/SHP-1.

Subcellular Location:
Cell membrane; Single-pass type I membrane protein.

Post-translational modifications:
Phosphorylated on tyrosine residues by LYN; this creates binding sites for PTPN6/SHP-1.

Similarity:
Contains 3 SRCR domains.

SWISS:
P06127

Gene ID:
921

Database links:
Entrez Gene: 921 Human
Omim: 153340 Human
SwissProt: P06127 Human
Unigene: 58685 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
 

产品图片	Flow cytometry staining of normal human peripheral blood cells with CD5/PE(bsm-30067M-PE)(Red histogram) or Mouse IgG1 Isotype Control (PE Conjugate)(C03-11002 )(Blue histogram) . Total cells were used for analysis.