FITC标记小鼠抗人CD38单克隆抗体

英文名称human CD38-FITC
中文名称FITC标记小鼠抗人CD38单克隆抗体
别    名ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1; 2'-phospho-ADP-ribosyl cyclase; 2'-phospho-ADP-ribosyl cyclase/2'-phospho-cyclic-ADP-ribose transferase; 2'-phospho-cyclic-ADP-ribose transferase; ADP-ribosyl cyclase 1; ADPRC 1; Cyclic ADP-ribose hydrolase 1; cADPr hydrolase 1; T10; CD38_HUMAN.  FITC anti-human CD38;
规格25T  100T  
研究领域肿瘤  免疫学  干细胞  糖尿病  细胞表面分子  糖蛋白  淋巴细胞  t-淋巴细胞  b-淋巴细胞  
抗体来源Mouse
克隆类型Monoclonal
交叉反应 Human, 
产品应用Flow-Cyt=20ul/Test （石蜡切片需做抗原修复） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量34kDa
细胞定位细胞膜 
性    状Liquid
免 疫 原: 
亚    型IgG
纯化方法affinity purified by Protein G
储 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
产品介绍background:
The protein encoded by this gene is a non-lineage-restricted, type II transmembrane glycoprotein that synthesizes and hydrolyzes cyclic adenosine 5'-diphosphate-ribose, an intracellular calcium ion mobilizing messenger. The release of soluble protein and the ability of membrane-bound protein to become internalized indicate both extracellular and intracellular functions for the protein. This protein has an N-terminal cytoplasmic tail, a single membrane-spanning domain, and a C-terminal extracellular region with four N-glycosylation sites. Crystal structure analysis demonstrates that the functional molecule is a dimer, with the central portion containing the catalytic site. It is used as a prognostic marker for patients with chronic lymphocytic leukemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Function:
Synthesizes cyclic ADP-ribose, a second messenger for glucose-induced insulin secretion. Also has cADPr hydrolase activity. Also moonlights as a receptor in cells of the immune system.

Subcellular Location:
Membrane; Single-pass type II membrane protein.

Tissue Specificity:
Expressed at high levels in pancreas, liver, kidney, brain, testis, ovary, placenta, malignant lymphoma and neuroblastoma.

Similarity:
Belongs to the ADP-ribosyl cyclase family.

SWISS:
P28907

Gene ID:
952

Database links:
Entrez Gene: 952 Human
Omim: 107270 Human
SwissProt: P28907 Human
Unigene: 479214 Human


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 
FITC标记小鼠抗人CD38单克隆抗体

产品图片	Flow cytometry staining of normal human peripheral blood cells with CD38/FITC(bsm-30080M-FITC)(Red histogram) or Mouse IgG2a Isotype Control (FITC Conjugate)(C03-12001)(Blue histogram) . Total cells were used for analysis.